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Why Homeopathy Needs Prolonged Treatment To Eradicate Deep Rooted Chronic Diseases?

In chronic diseases, Homeopathy needs prolonged treatment to completely cure the disease. During the process of treatment, we observe the appearance of various symptoms of detoxification through various routes, which disturb the patients. These processes of elimination of toxins are generally irritating to the patients. But without these disturbing symptoms, the complete cure cannot be achieved.

But the homeopathic physicians face hurdles to convince the patients not to use any alternative treatment to suppress those discharges. The scientists of conventional medicine never accepted this hypothetical concept of homeopathy and helped the patients to use all possible measures to suppress the discharges. Only recently, in case of diarrheal diseases, they are advising the patients to help the process of discharge by oral rehydration therapy and prevented the use of anti-diarrheal drugs.  Otherwise, they never found any harm in using steroids which suppressed the immune system by giving relief to the sufferings caused by painful symptoms of detoxification.

A recent invention presented below will show that the bacteria or virus remain well protected against any possible attack from the members of immune system, the T-cell and the B-cell and remain unharmed and cause disease by producing toxins.

Up till now, we are told by the scientists that, the micro-organisms are responsible for acute diseases only. But the above invention will show that they are responsible for chronic diseases also. This concept was postulated by Hahneman by the concept of miasm as the cause of chronic diseases, which could not be explained by any scientific evidence.    

 This invention will help us to make our patients convinced that such mighty viruses need persistent repeated and prolonged assault by the immune system to penetrate the barrier around the micro-organism. That type of vigorous repeated attack can only be applied by the repeated use of homeopathy drugs for a long period of time and by the method of selecting the drugs by symptom analogy, called similimum of homeopathy.

This will help the followers of homeopathy to explain many hypothetical concepts to establish homeopathy on a scientific ground.    

How Bacteria Build Homes Inside Healthy Cells

ScienceDaily (Dec. 20, 2011)
Bacteria are able to build camouflaged homes for themselves inside healthy cells --
and cause disease -- by manipulating a natural cellular process.

Purdue associate professor of biological sciences Zhao-Qing Luo, at right, and graduate student Yunhao Tan look at the growth of Legionella pneumophila bacteria in a petri dish. (Credit: Purdue University photo provided by Laurie Iten and Rodney McPhail)

Purdue University biologists led a team that revealed how a pair of proteins from the bacteria Legionella pneumophila, which causes Legionnaires disease, alters a host protein in order to divert raw materials within the cell for use in building and disguising a large structure that houses the bacteria as it replicates.

Zhao-Qing Luo, the associate professor of biological sciences who headed the study, said the modification of the host protein creates a dam, blocking proteins that would be used as bricks in cellular construction from reaching their destination. The protein "bricks" are then diverted and incorporated into a bacterial structure called a vacuole that houses bacteria as it replicates within the cell. Because the vacuole contains materials natural to the cell, it goes unrecognized as a foreign structure.

  • A vacuole is a membrane-bound organelle which is present in all plant and fungal cells and some protist, animal[1] and bacterial cells.[2] Vacuoles are essentially enclosed compartments which are filled with water containing inorganic and organic molecules including enzymes in solution, though in certain cases they may contain solids which have been engulfed.

    Vacuoles are formed by the fusion of multiple membrane vesicles and are effectively just larger forms of these.[3] The organelle has no basic shape or size; its structure varies according to the needs of the cell. #wikipedia definition

"The bacterial proteins use the cellular membrane proteins to build their house, which is sort of like a balloon," Luo said. "It needs to stretch and grow bigger as more bacterial replication occurs. The membrane material helps the vacuole be more rubbery and stretchy, and it also camouflages the structure. The bacteria is stealing material from the cell to build their own house and then disguising it so it blends in with the neighborhood."

The method by which the bacteria achieve this theft is what was most surprising to Luo. The bacterial proteins, named AnkX and Lem3, modify the host protein through a biochemical process called phosphorylcholination that is used by healthy cells to regulate immune response. Phosphorylcholination is known to happen in many organisms and involves adding a small chemical group, called the phosphorylcholine moiety, to a target molecule, he said.

The word moiety is often used synonymously to "functional group," but, according to the IUPAC definition,[3] a moiety is a part of a molecule that may include either whole functional groups or parts of functional groups as substructures. #wikipedia definition

The team discovered that AnkX adds the phosphorylcholine moiety to a host protein involved in moving proteins from the cell's endoplasmic reticulum to their cellular destinations. The modification effectively shuts down this process and creates a dam that blocks the proteins from reaching their destination.

The bacterial protein Lem3 is positioned outside the vacuole and reverses the modification of the host protein to ensure that the protein "bricks" are free to be used in creation of the bacterial structure.

This study was the first to identify proteins that directly add and remove the phosphorylcholine moiety, Luo said.

"We were surprised to find that the bacterial proteins use the phosphorylcholination process and to discover that this process is reversible," he said. "This is evidence of a new way signals are relayed within cells, and we are eager to investigate it."

The team also found that the phosphorylcholination reaction is carried out at a specific site on the protein called the Fic domain. Previous studies had shown this site induced a different reaction called AMPylation.

  • Figure 1. Proposed role for phosphorylcholine-specific autoantibodies in slowing the progression of atherosclerosis. Atherosclerotic plaque formation in the blood vessel wall initiates through uptake of LDL from blood by endothelial cells, and oxidation of LDL by reactive oxygen species within the vessel wall. Uptake of oxLDL by macrophages through scavenger receptors (such as CD36 and SR-A) leads to macrophage transformation into lipid-laden activated foam cells. Foam cells produce proinflammatory cytokines and matrix metalloproteinases and express costimulatory molecules for T-cell activation (such as CD40). All of this promotes the proinflammatory milieu and atherogenesis. In addition, foam cells produce large quantities of myeloperoxidase, an enzyme that produces reactive oxygen species, thereby stimulating oxidation of LDL and further promoting the vicious cycle. The production of IgM-specific antibodies increases during atherogenesesis (and is enhanced by pneumococcal vaccination). These antibodies may be able to cross the endothelial barrier to reach the atherosclerotic lesion. There, they bind to antigens on the surface of oxLDL, forming immune complexes and blocking the uptake of oxLDL by macrophages. In addition, phosphorylcholine-specific IgM may bind oxLDL in the circulation, facilitating its clearance and making it unavailable for plaque formation

It is rare for a domain to catalyze more than one reaction, and it was thought this site's only responsibility was to transfer the chemical group necessary for AMPylation, Luo said.

"Revealing that this domain has dual roles is very important to identify or screen for compounds to inhibit its activity and fight disease," he said. "This domain has a much broader involvement in biochemical reactions than we thought and may be a promising target for effective treatments."

During infection bacteria deliver hundreds of proteins into healthy cells that alter cellular processes to turn the hostile environment into one hospitable to bacterial replication, but the specific roles of only about 20 proteins are known, Luo said.

"In order to pinpoint proteins that would be good targets for new antibiotics, we need to determine their roles and importance to the success of infection," he said. "We need to understand at the biochemical level exactly what these proteins do and how they take over natural cellular processes. Then we can work on finding ways to block these activities, stop the infection and save lives."

A paper detailing their National Institutes of Health-funded work is published in the current issue of the Proceedings of National Academy of Sciences. In addition to Luo, Purdue graduate student Yunhao Tan and Randy Ronald of Indiana University co-authored the paper. Luo next plans to use the bacterial proteins as a tool to learn more about the complex cellular processes controlled by phosphorylcholination and to determine the biochemical processes role in cell signaling.

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Comment by Dr Muhammed Rafeeque on January 17, 2012 at 7:02am

It takes several years for the complete development of the disease as a result of repeated suppressions one after the other. Hence, the treatment also takes little time to cure the patient layer by layer.

Comment by Debby Bruck on January 10, 2012 at 12:19am

Dear Dr Rashid. I hope many people will visit and read your thought provoking article. Learning that homeopathic remedies must be given over a long period of time on a consistent basis to initiate and sustain cure in chronic cases seems to be the trend in many clinics today.

We learn that giving one dose and waiting does not last, nor is it effective for complicated auto-immune diseases due to pollution, vaccinations, unpure food products, environmental toxins and synthetics, and radiation, etc that has impacted our systems. I imagine that humans will be evolving and as Darwin would say, "survival of the fittest" and those that have certain hereditary genes to withstand the onslaught of these chemicals, etc will have health.

With homeopathy, we may yet see the return to healthy state. Blessings, Debby

P.S. I clicked "LIKE" and will share on twitter and FaceBook.

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