Glyphosate is an active ingredient of the most widely used herbicide and it is believed to be less toxic than other pesticides. However, several recent studies showed its potential adverse health effects to humans as it may be an endocrine disruptor. This study focuses on the effects of pure glyphosate on estrogen receptors (ERs) mediated transcriptional activity and their expressions. Glyphosate exerted proliferative effects only in human hormone-dependent breast cancer, T47D cells, but not in hormoneindependent breast cancer, MDA-MB231 cells, at 10(-12) to 10(-6) M in estrogen withdrawal condition. The proliferative concentrations of glyphosate that induced the activation of estrogen response element (ERE) transcription activity were 5-13 fold of control in T47D-KBluc cells and this activation was inhibited by an estrogen antagonist, ICI 182780, indicating that the estrogenic activity of glyphosate was mediated via ERs. Furthermore, glyphosate also altered both ERα and βexpression. These results indicated that low and environmentally relevant concentrations of glyphosate possessed estrogenic activity. Glyphosate-based herbicides are widely used for soybean cultivation, and our results also found that there was an additive estrogenic effect between glyphosate and genistein, a phytoestrogen in soybeans. However, these additive effects of glyphosate contamination in soybeans need further animal study.
Entropy| Scientific Journal Publication | Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases Abstract:Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise. Residues are found in the main foods of the Western diet, comprised primarily of sugar, corn, soy and wheat. Glyphosate's inhibition of cytochrome P450 (CYP) enzymes is an overlooked component of its toxicity to mammals. CYP enzymes play crucial roles in biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging effects of other food borne chemical residues and environmental toxins. Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body. Here, we show how interference with CYP enzymes acts synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria, as well as impairment in serum sulfate transport. Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.
The American public are being told a FALSE MESSAGE that use of herbicides and pesticides will REDUCE the need for more when in actuality the use of GM with INCREASE the need for even more deadly chemicals.
Uncontrollable threat of Genetically Modified Pollen through DRIFT carried by wind, birds and insects and the water ways resulting in these problems:
The documentary A Silent Forest: The Growing Threat, Genetically Engineered Trees discusses how genetically engineered (GE) trees may adversely impact ecological systems on a grand scale, with potentially catastrophic effects
Trees are being genetically altered to give them unnatural characteristics, such as the ability to kill insects, tolerate toxic herbicides, grow abnormally fast, or have decreased lignin for the convenience of the paper industry
Genetically engineered trees vastly differ from annual GE crops like corn and soybeans because trees can live for decades and even centuries in the wild; once GE trees escape the confines of their plantation, they are extremely difficult, if not impossible, to eradicate
Many trees are able to spread their seeds and pollen for hundreds and even thousands of miles, making native forests vulnerable to cross-contamination, which poses an enormous threat to worldwide ecosystems
The biotech industry and US government are rushing ahead without performing appropriate safety studies, doing everything they can to hasten the approval of GE technology while silencing the opposition
GE Trees May Be Even More Damaging to the Environment than GE Foods
What will it take to stop the monster Monsanto and other corporations bent on the destruction of our planet. Most people cannot imagine than any human in their right mind would create a sterile environment, uninhabitable by insects, birds, bees, worms, plants and all living beings, including people. The path of GMO to sterilize trees that produce our food, including fruits and nuts, is total insanity and unsustainable to life on earth. What is the goal and how can we allow this action to continue? Please speak to your representatives and get them involved. Speak through the power of the purse. It will cost a little more at the market to buy organic, but in the long run it will save a life. You can think of it as your donation to the cause.
Huffington Post | April 25 (Reuters) - Heavy use of the world's most popular herbicide, Roundup, could be linked to a range of health problems and diseases, including Parkinson's, infertility and cancers. scientific journal Entropy, said evidence indicates that residues of "glyphosate," the chief ingredient in Roundup weed killer, which is sprayed over millions of acres of crops, has been found in food.