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Efficacy of Homoeopathy in Treatment of Sarcoidosis – An Evidence Based Report Based On 50 Cases

Only abstract is given here. 

To see the complete thesis with images and charts, pl. see attached pdf.

Efficacy of Homoeopathy in Treatment of Sarcoidosis 50 cases.pdf

Abstract

To ascertain efficacy of Homoeopathy in treatment of sarcoidosis, 50 cases during the period since 2007-2013 were selected for study at Homoeo Cure and Research Institute., Kashipur (INDIA). The efficiency of homoeopathic treatment was miraculously seen in all the cases. Almost all were either cured or much relieved.

Aims and objectives

  • To study scope of Homoeopathy in treatment of ‘Sarcoidosis’ with its miasmatic analysis.
  • To analyze the results of Homoeopathic medicines when prescribed on the basis of Miasms and on totality of symptoms.
  • To prepare evidence based report on treatment of Sarcoidosis with Homoeopathy.

Introduction

‘Sarcoidosis’ is a ‘not well understood’ complex multisystem, commonplace inflammatory disease, characterized by the formation of noncaseating granulomas. The granuloma is a battle clashed on a genetically susceptible ground between an unrecognized antigen(s) and a highly organized squad of lymphocytes and macrophages. The lungs are the most commonly involved organs, but no structure of the body is known to be immune to its wrecks.

The cause of sarcoidosis is not known till now. Though not common, it often leads to permanent failure or disabilities of the organs ultimately leading to the end of vital functions.

‘Sarcoidosis’, like other disease, affects the person as a whole irrespective of the cause. The whole economy of the patient is altered producing the signs of ‘Sarcoidosis’ as well as a characteristic picture of sick individual including mental and physicals specific to his personality. This disease picture specific to that particular patient is always different from that in another one due to his particular identity proving him to be an ‘Individual’. The totality of symptoms depends upon the Miasms under-running the disease process in that individual.  

The Psora being the fundamental miasm plays maximum role in altering the physiology rendering the entire imbalance. While in combination with other miasms, it produces the worst stage of the sickness. The syphilis produces destruction of tissues. To combat it, Sycosis and Psora play their vital part. This combination in turn increases the destruction as well as new tissue formation too, producing granulomas and fibromas publishing the complete portrait of Sarcoidosis.

This article examines the current understanding of sarcoidosis in terms of Homoeopathy.

Definition of Sarcoidosis

"Sarcoidosis is a disease characterized by the formation in all of several affected tissues of epithelioid-cell tubercles without caseation though fibrinoid necrosis may be present at the centre of a few, proceeding either to resolution or to conversion into hyaline fibrous tissue".

Epidemiology of Sarcoidosis

  • Age at presentation 20–40 years
  • More common in females and black people
  • Present throughout the world, but more common in temperate climates

Causes of Sarcoidosis

Possible Causes of Sarcoidosis

Mycobacteria

Bacteria

Fungi

Viruses

Dusts

Metals

Tuberculous

Corynebacterium spp.

Cryptococcus spp.

Cytomegalovirus

Clay

Aluminum

Non-tuberculous

Propionibacterium

Endemic fungi

Epstein-Barr virus

Pine

Beryllium

Cell-wall deficient

(L-forms)

acnes

 

 

Herpes simplex virus

Pollen

 

Zirconium

 

 

Tropheryma whippleii

 

Talc

 

Mixed

Signs and Symptoms of ‘Sarcoidosis’ with Miasmatic Analysis

  • Up to one-third are asymptomatic
  • Acute presentation (Lofgren’s syndrome) with fever, malaise, arthralgia, erythema nodosum and uveitis
  • Chronic presentation with fever, weight loss, dry cough or SOB
  • Symptoms are usually mild if thoracic disease only

Rarer presentations include-

  • Hypercalcaemia (renal stones, constipation and dehydration)
  • Red eyes
  • Skin rashes
  • Central and peripheral nerve palsies
  • Hypothalamic deficiency
  • Bilateral salivary gland enlargement
  • Cardiomyopathy or arrhythmias

Sign or Symptom

Fundamental Miasm

Secondary/ Associated Miasm

General discomfort, uneasiness, or ill feeling (malaise)

Psora

Psora- Syphilis

Fever

Psora

 

Shortness of breath

Psora

Sycosis

Cough

Psora

Sycosis, Syphilis

Skin lesions

Psora

Sycosis

Skin rash

Psora

 

Headache

Psora

Sycosis, Syphilis

Visual changes

Psora-Sycosis-Syphilis

 

Neurological changes

Sycosis-Syphilis

Psora

Enlarged lymph glands (armpit lump)

Psora

Sycosis

Enlarged liver

Psora

Sycosis

Enlarged spleen

Psora

Sycosis

Dry mouth

Psora

 

Fatigue (one of the most common symptoms in children)

Psora

Syphilis

Weight loss (one of the most common symptoms in children)

Psora-Syphilis

 

Tearing, decreased

Psora

Sycosis, Syphilis

Seizures

Psora

Psora- Syphilis

Nosebleed - symptom

Psora- Syphilis

 

Joint stiffness

Psora

Sycosis

Hair loss

Psora

Sycosis, Syphilis

Eye burning, itching, and discharge

Psora

Psora- Syphilis

Abnormal breath sounds (e.g. rales)

Psora- Syphilis

Sycosis

Radiological features of Sarcoidosis

CXR

  • May be normal.
  • Stage 1 – bilateral hilar and mediastinal lymphadenopathy (particularly right paratracheal and aortopulmonary window nodes).
  • Stage 2 – lymphadenopathy and parenchymal disease.
  • Stage 3 – diffuse parenchyma disease only.
  • Stage 4 – pulmonary fibrosis.

The parenchymal disease involves reticulonodular shadowing in a perihilar, mid zone distribution. There is bronchovascular and fissural nodularity. Rarely air space consolidation or parenchymal bands may also be present. Fibros is affects the upper zones where the hilar are pulled superiorly and posteriorly. Lymph nodes can demonstrate egg shell calcification.

HRCT

Very good at confirming irregular septal, bronchovascular and fissural nodularity. Traction bronchiectasis, fibrosis and ground glass change may be present. There may also be tracheobronchial stenosis. Also may be seen subdiaphragmatic, cardiac, bone, hepatic and splenic involvement on the same scan.

Radiological Differential diagnosis

  • Lymphoma
  • Infection – TB
  • Lymphangitis carcinomatosis
  • Chronic hypersensitivity pneumonitis

Clinical Staging of Sarcoidosis

Stage 0

 A normal chest radiograph

Stage I

 Lymphadenopathy only

Stage II

 Lymphadenopathy and lung parenchymal disease

Stage III

 Parenchymal lung disease only

Stage IV

 Pulmonary fibrosis

Diagnosis of Sarcoidosis

  • Histological evidence of granulomatous inflammation.
  • The exclusion of the known causes of granulomatous inflammation other than sarcoidosis.
  • Evidence of at least two separate organs involved with the disease.

Examinations and Tests for Sarcoidosis

  • CBC, Chem-7 or Chem-20, ACE levels
  • Chest x-ray to see if the lungs are involved or lymph nodes are enlarged and CT scan
  • Biopsy of  Lymph node, Skin lesion biopsy, lung, Liver, Kidney
  • Bronchoscopy and PFT
  • EKG to see if the heart is involved

Common Complications of Sarcoidosis

  • Diffuse interstitial pulmonary fibrosis and / or Pulmonary hypertension
  • Anterior uveitis and / or Glaucoma and blindness (rare)
  • Cardiac arrhythmias
  • Cranial or peripheral nerve palsies
  • Kidney stones
  • Organ failure, leading to the need for a transplant

Treatment of Sarcoidosis

 

Treatment of Sarcoidosis

Main Goals of treatment

The treatment depends on

To improve how the organs affected by sarcoidosis work

Involvement of vital organs (e.g., lungs, eyes, heart, or brain)

To relieve symptoms

Severity of symptoms

To shrink the granulomas

Extent of affection of the organs.

Sarcoidosis and Homoeopathy

In clinical study carried out at Homoeo Cure and Research Institute, Kashipur, total 50 cases of Sarcoidosis were considered. The following results were observed in the research.

 Discussions

Prevalance of Sarcoidosis on basis of Sex

Sarcoidosis was found more prevalent in Male patients (52%) than Females (48%).

Prevalance of Sarcoidosis on basis of Age

Sarcoidosis was found most prevalent in age group 41-50 years (30%) and least in below 20 and above 60 years of ages (all 2%). Age groups 21-30, 31-40 and 51-60 showed almost equal prevalence (20-22 %).

Prevalance of Sarcoidosis on basis of Occupation

The prevalence of Sarcoidosis was mostly in working patients (56%), house wives (26%), Students (12%) and non-working ones (06%).

Prevalance of Sarcoidosis on basis of Marital Status

Sarcoidosis was found more prevalent in married patients (88%) than single ones (12%).

 

Prevalance of Sarcoidosis on basis of Caste

Sarcoidosis was found in mostly in Hindus (76%) and least in Christians (4%), in Muslims 12% and in Sikhs 8%. (As per Indian Population).

Prevalance of Sarcoidosis on basis of Physical Built

Sarcoidosis was found in moderate built individuals (46%), obese (22%), thin (32%).

 Prevalance of Sarcoidosis on basis of Diagnosis

The most frequent was Sarcoidosis pulmonary (49%), with arthritis (21%), skin lesions (5%), uveitis (6%), with Cardiac (6%), with Neuorological (8%) and with Nephrological manifestations (5%).

Prevalance of Sarcoidosis on basis of Miasms

The most frequent miasm was found to be Sycosis (38%). Others being Psora (34%), Pseudopsora (17%) and Syphilis (11%).

Prevalance of Sarcoidosis on basis of Menstrual History

Sarcoidosis was found most common in females with normal menses (31%) and in postmenopausal ones (31%). It was the least seen in nonmenstruating females including prepubertal cases (2%) and sterile ones (2%). In females with profuse menses, it was 7%.

Prevalance of Sarcoidosis on basis of Family Income

Sarcoidosis seen most common in good family income group (48%), least in poor ones (14%) and moderate in average income group (38%).

 Prevalance of Sarcoidosis on basis of Choice of Remedies

First Remedy

The most indicated remedy in first prescription was Pulsatilla (30%), next Tunerculinum (14%) and the third one was Rhus tox (12%).

Second Remedy

The most indicated remedy in second prescription was Pulsatilla (19%), next Beryllium met (13%) and then Natrum mur (9%).

 Third Remedy

The most indicated remedy in third prescription was Bryonia (29%), next Colchicum (15%) and then Oleander, Carcinosin, Pulsatilla and Arnica, all 14%.

Prevalance of Sarcoidosis on basis of Basis of Prescription

Most of the cures of Sarcoidosis were seen with constitutional treatment (82%) pathological prescribing (18%).

Prevalance of Sarcoidosis on basis of Basis of Prescription

38% os Sarcoidosis cases were cured and 62% relieved. There was no case which was not relieved with Homoeopathy.

Prevalance of Sarcoidosis on basis of Basis of Prescription

The highiest percentage of cure was in Sycosis (22%) with 22% relieved, Psora 12% cured and 32% relieved, Syhilis 10% cured with 2% relieved and Pseudopsora 8% cured with 16% relieved.

Miasm

Cure

Relief

Psora

6

16

Pseudopsora

4

8

Sycosis

11

11

Syphilis

5

1

Prevalance of Remedies on basis of Basis of frequency of indication

Remedies used

Cure

Relief

Score (10 for Cure + 5 for Relief)

Pulsatilla

7

18

160

Tuberculinum

6

1

65

Rhus tox

3

6

60

Beryllium met

1

9

55

Lycopodium

2

3

35

Thuja

1

5

35

Ars iod

3

30

Iodium

3

30

Bryonia

2

20

Natrum mur

4

20

Phosphorus

4

20

Sulphur

2

20

Arnica

1

1

15

Carcinosin

3

15

Causticum

1

1

15

Plumbum met

3

15

Argentum nit

2

10

Aur met

1

10

Cicuta verosa

1

10

Colchicum

1

10

Digitalis

2

10

Dulcamara

1

10

Gelsemium

1

10

Ruta

1

10

Ammonium mur

1

5

Ignatia

1

5

Medorrhinum

1

5

Oleander

1

5

Grades of the remedies as per frequency of indication in this study were Pulsatilla > Tuberculinum > Rhus tox > Beryllium met > Lycopodium > Thuja > Ars iod > Iodium > Bryonia > Natrum mur > Phosphorus > Sulphur > Arnica > Carcinosin > Causticum > Plumbum met > Argentum nit > Aur met > Cicuta verosa > Colchicum > Digitalis > Dulcamara > Gelsemium > Ruta > Ammonium mur > Ignatia > Medorrhinum > Oleander.

Thus, we can see that Pulsatilla was the most important and most indicated remedy in Sarcoidosis.

Prevalance of Remedies on basis of Basis of result

Remedies used

Cure

Relief

Score

= {(10 for Cure + 5 for Relief)/

no. of cases}

Ars iod

3

10

Iodium

3

10

Bryonia

2

10

Sulphur

2

10

Aur met

1

10

Cicuta verosa

1

10

Colchicum

1

10

Dulcamara

1

10

Gelsemium

1

10

Ruta

1

10

Tuberculinum

6

1

9.28

Arnica

1

1

7.5

Causticum

1

1

7.5

Lycopodium

2

3

7

Rhus tox

3

6

6.66

Pulsatilla

7

18

6.4

Thuja

1

5

5.83

Beryllium met

1

9

5.5

Natrum mur

4

5

Phosphorus

4

5

Carcinosin

3

5

Plumbum met

3

5

Argentum nit

2

5

Digitalis

2

5

Ammonium mur

1

5

Ignatia

1

5

Medorrhinum

1

5

Oleander

1

5

Thus we can clearly see that the most effective cures are met with Ars iod, Iodium, Bryonia, Sulphur, Aur met, Cicuta verosa, Colchicum, Dulcamara, Gelsemium and Ruta.

The next important remedies are Tuberculinum, Arnica, Causticum, Lycopodium, Rhus tox, Pulsatilla, Thuja, Beryllium met.

Another ones are Natrum mur, Phosphorus, Carcinosin, Plumbum met, Argentum nit, Digitalis, Ammonium mur, Ignatia, Medorrhinum, Oleander.

Conclusion

The above study confirms the efficacy of Homoeopathy in treatment of Sarcoidosis in all stages and all types, with amazing success when applied as per laws of similia and proves its superiority among all the existing streams of treatment.

All the reports and details of every patient are kept secret to avoid disclosure of their identity and can be seen in our records if needed.

Views: 3138

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Comment by Dr Rajneesh Kumar Sharma MD(Hom) on July 25, 2013 at 7:23am

Thanks Dr. Faridul. Regards......

Comment by faridul islam on July 25, 2013 at 6:46am

It remind us the works of Bonninghousen. A true scientific study. Bravo.

Comment by Dr Rajneesh Kumar Sharma MD(Hom) on July 5, 2013 at 12:05am

Thanks sir...

Comment by Dr. Sayed Tahir Hassan on July 4, 2013 at 12:39pm

Fantastic work Dr. Rajneesh. I am overwhelmed to see this study.

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