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Prader-Willi syndrome and Homoeopathy

 

Rajneesh Resource Page

Copyright 2011-2/All rights reserved © Dr Rajneesh 
Contact author for permission to use

 

Prader-Willi syndrome (PWS) is a single gene imprinting disorder (Psora/ Syphilis) caused by defects in chromosome 15. These defects may be of two types-

1. Paternally inherited deletion or disruption of genes in the proximal arm of chromosome 15. (Syphilis)

2. Maternal disomy in the proximal arm of chromosome 15. (Psora)

Related words

Cryptorchidism-dwarfism-subnormal mentality; hypogenital dystrophy with diabetic tendency; hypotonia-hypomentia-hypogonadism-obesity syndrome; Labhart-Willi syndrome; Prader-Labhart-Willi Fancone syndrome; Willi-Prader syndrome.

Historical Background

The first patient with Prader-Willi syndrome was described by Langdon-Down In 1887 as an adolescent girl with mental impairment (Psora), short stature (Psora), hypogonadism (Psora), obesity (Psora). He called these symptoms to polysarcia.

In 1956, Prader et al reported some patients with similar phenotypes.

In 1981, Ledbetter et al identified microdeletions (Syphilis) within chromosome 15 and determined it to be the site for Prader-Willi syndrome.

Pathophysiology

Prader-Willi syndrome is the first human disorder recognized to genomic imprinting. In such disorders, genes are expressed differentially based on the parent of origin. It results from the loss of imprinted genomic material within the paternal 15q11.2-13 locus. The loss of maternal genomic material (Syphilis) at the 15q11.2-13 locus results in Angelman syndrome.

Most cases of Prader-Willi syndrome that involve deletions (Syphilis), unbalanced translocations (Psora), and uniparental (maternal) disomy (Psora) are sporadic.

Epidemiology

Most cases of Prader-Willi syndrome are sporadic with a prevalence rate of 1 per 25,000 population.

Mortality/Morbidity

It is due to complications due to obesity e.g., slipped capital femoral epiphyses, sleep apnoea, cor pulmonale, type 2 diabetes mellitus.

Behavioural problems are major contributors to morbidity and mortality in individuals with Prader-Willi syndrome. It is a genetic disorder with lifelong implications.

History

Infants

Hypotonia (Psora), poor suck (Psora), weak cry (Psora), and genital hypoplasia (Psora) (e.g., cryptorchidism, scrotal hypoplasia, clitoral hypoplasia).

Toddlers

Major motor milestones delayed. (Psora)

Children

Hyperphagia (Psora) with progressive development of obesity (Psora).

Short stature (Psora) with lack of pubertal growth shot (Syphilis).

Sleep disturbances (Psora), obstructive sleep apnea and narcolepsy (Psora).

Growth hormone deficiency (Psora).

Premature growth of pubic and axillary hair (Psora) but other features of Prader-Willi syndrome are usually delayed or incomplete.

Testicular descent late (Psora) ; menarche may occur as late as age 30 (Psora).

Features of psychosis and behavioural problems- temper outbursts (Psora), stubborn (Psora), and obsessive-compulsive behaviour (Psora), eating garbage (Psora) and frozen food (Psora), and stealing resources to obtain food (Psora) leading to gastric complications, gastric necrosis (Psora/ Syphilis) and even death.

Mild mental retardation (Psora).

Obesity complications- sleep apnoea (Psora), cor pulmonale (Psora/ Sycosis), diabetes mellitus (Pseudopsora), atherosclerosis (Sycosis).

Dysmorphic findings in a child with Prader-Willi syndrome include narrowing of the temples, almond-shaped eyes, strabismus, and a thin upper lip.

Physical

Holm et al established the following diagnostic criteria for Prader-Willi syndrome. Score 1 point for each major criterion and 0.5 point for each minor criterion. A diagnosis of Prader-Willi syndrome should be suspected in children younger than three years with a score of at least 5; and in children three years and older with a score of at least 8, with 4 points from major criteria. Supportive criteria (no points) include high pain threshold, decreased vomiting, temperature control problems, scoliosis, kyphosis, early adrenarche, osteoporosis, unusual skill with jigsaw puzzles, and normal neuromuscular studies.

Diagnostic Criteria for Prader-Willi Syndrome

Causes

Prader-Willi syndrome is due to the loss of the paternal copy (Syphilis) of chromosome 15q11.2-13.

More than 70% of patients have a deletion of the paternal copy (Syphilis); approximately 25% of patients with Prader-Willi syndrome have maternal uniparental disomy (Psora) in chromosome 15. The remainder of patients with this disorder have a translocation or other structural alteration (Psora) in chromosome 15.

Most manifestations of Prader-Willi syndrome are attributable to hypothalamic dysfunction.

Clinical picture

Clinical features of Prader–Willi syndrome

Facies Narrow forehead

Almond-shaped eyes

Down-turned mouth

Triangular upper lip; ‘carp-like’ mouth

Upturned retroussé´ nose

High arched palate

Musculo-skeletal

Central origin muscular hypotonia

Scoliosis

Small hands and feet

Flat ulnar border to hands

Tapering fingers and toes

Short stature

Hypothalamic abnormalities

Cryptorchidism

Micropenis

Small female genitalia

Delayed or absent pubertal development

Primary or secondary amenorrhoea

Psychodevelopmental problems

Delayed motor development

Delayed language development

Learning difficulties

Cognitive difficulties

Temper tantrums

Controlling/manipulative behaviours

Food seeking behaviour

Stubbornness

Cutaneous problems

Self-inflicted wounds on arms particularly

Intertrigo in fat folds with secondary Candida infection

Phlebitis and ulceration of oedematous legs

Nutritional state

Feeding problems in early life: failure to thrive

Later insatiable appetite: gross obesity

Co-morbidities

Cardiorespiratory problems

Obstructive sleep apnoea

Type 2 diabetes mellitus

Osteoporosis

Differential Diagnoses

Anxiety Disorder: Obsessive-Compulsive Disorder

Cryptorchidism

Failure to Thrive

Fragile X Syndrome

Growth Hormone Deficiency

Hypogonadism

Obesity

Obesity-Hypoventilation Syndrome and Pulmonary Consequences of Obesity

Obstructive Sleep Apnoea Syndrome

Osteoporosis

Short Stature

Sleep Apnoea

Laboratory Studies

Genetic testing

It includes chromosomal analysis and assessment for methylation patterns in the Prader-Willi syndrome region.

Analysis for underlying uniparental disomy requires samples from both parents and the child with Prader-Willi syndrome.

Fluorescent in situ hybridization (FISH) can be used to confirm prenatal diagnosis when a deletion in the 15q region is suspected after chorionic villus sampling or amniocentesis.

Hormone testing

Fasting measurements of serum insulinlike growth factor-1 (IGF-1) and insulinlike growth factor binding protein-3 (IGFBP-3) levels are good screening measurements for underlying growth hormone deficiency.

Assessment of thyroid,  Hypopituitarism and adrenal status.

Obesity

Glycosylated hemoglobin

Tests for Pickwickian syndrome e.g. hypercarbia, polycythemia

Sleep study with multiple sleep latency testing.

Imaging Studies

MRI of the head for pituitary.

Serial dual energy x-ray absorptiometry (DEXA) scanning for detection and monitoring of osteoporosis.

X ray films for Scoliosis.

Chest radiography for cor pulmonale.

X ray extremities for limp evaluation, hip films to screen for hip dysplasia.

Abdominal radiography.

Abdominal ultrasonography, CT scanning and gastrointestinal series for acute gastric dilation, cholelithiasis, or pancreatitis.

Management and Treatment

Initial management of hypotonia or poor feeding.

Management of obesity and scoliosis and osteoporosis and diabetes mellitus.

Behavioural Therapy.

Occupational and physical therapy to promote acquisition of gross and fine motor skills and to strengthen spinal musculature in order to minimize scoliosis.

Encouragement of physical activity at home, at school is essential for modulation of weight.

Surgical Care for treatment of complications of obesity, treatment of cryptorchidism, scoliosis intervention and abdominal issues. Tonsillectomy, adenoidectomy, or tracheostomy placement may be required in patients with obstructive sleep apnoea.

Homoeopathic Treatment

Short repertory of Prdaer Willi Syndrome—

BACK - CURVATURE of spine - Lateral curve- sil.

BACK - CURVATURE of spine- acon. agar. ant-c. ASAF. aur. bar-c. Bar-m. bell. bry. CALC-F. calc-i. Calc-p. CALC-S. CALC. Carb-v. carbn-s. caust. cic. clem. coloc. Con. dros. dulc. ferr-i. hecla hep. ip. kali-c. lach. Lyc. MERC-C. Merc. mez. nat-c. nat-m. nux-v. op. PH-AC. Phos. plb. psor. Puls. rhus-t. ruta sabin. sep. SIL. staph. SULPH. syph. tarent. ther. thuj. tub.

BLADDER - URINATION – involuntary- abies-c. acet-ac. Acon. agar. AIL. alco. allox. Aloe alum-sil. Alum. alumn. am-c. am-m. anac. anan. androc. ant-c. ant-t. antip. APIS apoc. arbin. Arg-met. ARG-N. arist-cl. Arn. ARS-I. ARS. asthm-r. atro. aur-m. aur-s. bamb-a. bapt. Bar-act. Bar-c. bar-i. bar-m. BELL. benz-ac. borx. brach. Bry. Bufo cact. calam. calc-i. Calc-p. calc-sil. calc. Camph. cann-i. cann-s. Canth. caps. carb-an. Carb-v. carbn-dox. carbn-s. carc. casc. CAUST. Cedr. cere-s. cham. chen-a. chen-v. Chin. chinin-ar. chlam-tr. chlol. Cic. cimic. Cimx. Cina clem. cob-n. cocc. Colch. coloc. Con. crot-h. cub. cupr. cycl. dam. daph. der. Dig. dios. dros. DULC. Echi. epig. Equis-h. ery-a. eucal. eup-per. Eup-pur. ferr-ar. ferr-i. Ferr-p. ferr. Fl-ac. galla-q-r. Gels. graph. grat. guaj. Guare. ham. Hell. Hep. Hydr-ac. Hydr. hydrang. Hyos. Ign. Iod. ix. kali-ar. kali-br. kali-c. kali-cy. kali-m. kali-n. Kali-p. Kreos. Lac-c. lac-d. Lach. lat-m. lath. Laur. led. lina. Lup. LYC. lycpr. lyss. m-arct. m-aust. mag-c. mag-m. mag-p. mag-s. mand. med. meny. merc-c. Merc. mill. morg-g. Mosch. Mur-ac. Nat-ar. Nat-c. NAT-M. nat-p. nat-s. nat-sil. Nit-ac. nitro-o. NUX-M. Nux-v. oena. ol-j. Olnd. oncor-t. Op. ox-ac. pareir. Petr. Ph-ac. PHOS. phys. physala-p. pic-ac. pix Plan. plb. plut-n. Podo. PSOR. PULS. pyrog. rad-br. rat. rheum rhus-a. RHUS-T. rumx. russ. Ruta sabal sang. Sanic. santin. sapin. sars. scroph-xyz. Sec. Sel. senec-j. seneg. SEP. sil. Spig. Spong. Squil. STAPH. still. Stram. stront-c. stry-xyz. stry. sul-ac. sul-i. sulfonam. Sulph. symph. syph. tab. Tarax. tarent. Ter. Thuj. thyr. til. tritic-vg. tritic. tub. uran-n. urt-u. ust. Uva Verat. Verb. vesp-xyz. vesp. vib. viol-t. visc. xero. zinc-p. zinc.

EXTREMITIES – SWELLING- absin. acet-ac. apis aran-ix. Arist-cl. Arn. ars. aur-ar. Bamb-a. Bar-c. both. bros-gau. but-ac. buth-a. cadm-met. calc-ar. calc-f. carb-v. Cardios-h. cary. chin. chinin-s. chord-umb. cob-n. conch. cortico. cortiso. crot-h. Dulc. fuma-ac. hip-ac. kali-ar. kali-p. Kalm. lach. lat-m. med. MERC-SUL. merc. morg-p. nat-ar. nat-pyru. op. oxal-a. Petr. plb. rauw. rhus-t. ribo. ruta Sec. Sil. spig. spong. still. suis-pan. tritic-vg. vanil. vip. x-ray

FEMALE GENITALIA/SEX - ATROPHY – Ovaries- apis bar-c. Bar-m. Carbn-s. Con. helon. IOD. orch. ov. plb. x-ray

FEMALE GENITALIA/SEX - ATROPHY – Uterus- BAR-C. calen. caul. iod. plb. ust.

FEMALE GENITALIA/SEX – ATROPHY- bufo

FEMALE GENITALIA/SEX - INFANTILISM; genital- bar-c. calc-hp. calc-p. chim. con. ferr. helon. iod. Ov. phos. senec.

FEMALE GENITALIA/SEX - MENSES - delayed in girls, first menses- Abrom-a. acon. agn. alet. am-c. ant-c. apis aur-s. Aur. Bar-c. bar-m. bry. Calc-p. calc-s. Calc. Carbn-s. castm. caul. CAUST. chel. cic. cimic. cocc. Con. croc. cupr. dam. dig. dros. dulc. Ferr. GRAPH. guaj. Ham. helon. hyos. KALI-C. Kali-p. kali-perm. lac-d. lach. lith-f. Lyc. Mag-c. mag-m. Mang. merc. nat-lac. NAT-M. Petr. phos. polyg-h. PULS. sabad. Sabin. sang. sars. SENEC. Sep. sil. spig. staph. stram. stront-c. Sulph. Tub. valer. verat. vib. Zinc.

GENERALS - DEVELOPMENT – slow- bac. bar-c. bufo calc-p. Calc. caust. cupr. kreos. lac-d. mag-m. med. nat-m. pin-s. sil. sulph. thyr. toxo-g.

GENERALS - DIABETES MELLITUS- abrom-a. acet-ac. adren. aether alf. all-s. allox. aloe alumn. am-act. anthraco. apoc. arg-met. arg-n. arist-m. Ars-br. ars. asc-c. aspar. aur-m-n. aur. bar-m. Bor-ac. bov. brid-fr. calc-p. calc-sil. calc. canth. carb-ac. carb-v. carc. card-m. Carl. caust. cean. cephd-i. chel. chim. Chion. chlol. chlorpr. clem. coca cod. coff. coloc. con. cop. cortico. cortiso. cub. cupr-act. cupr-ar. cupr. cur. eup-pur. ferr-i. ferr-m. ferr-p. fl-ac. flor-p. friedr. gal-ac. galeg. glyc. Gymne. hed. helon. hydrang. hygroph-s. indgf-a. ins. Inul. iod. iris kali-act. kali-br. kali-chl. kali-i. kali-p. kiss. kreos. Lac-ac. lac-d. lach. led. lept. lith-c. lyc. lycps-v. mag-act. mag-o. mag-p. mag-s. mang-act. med. meny. merc-d. merc. moni. morind-l. morind-m. morph. mosch. mur-ac. murx. nat-ch. nat-lac. nat-m. nat-p. NAT-S. nauc-l. nep. nit-ac. nux-v. Op. orthos-s. oxyg. pancr. peps. perh. ph-ac. Phase. phlor. phos. pic-ac. pilo. plan. plb. podo. rad-br. rad-met. ran-b. rat. Rhus-a. rhus-r. rhus-t. sacch-l. sal-ac. sanic. sarcol-ac. saroth. sep. Ser-ang. sil. spong. Squil. stict. stront-c. stry-ar. sul-ac. sulfonam. sulph. syph. SYZYG. tarent. TER. Terebe. term-a. thuj. thyr. uran-m. Uran-n. Urea vanad. vichy-g. vinc-r. vince.

GENERALS – HYPOTONY- atra-r. gels. Psor. ser-a-c.

GENERALS - INFLAMMATION - Blood vessels – Veins- acon. agar. All-c. ant-c. Ant-t. apis arist-cl. Arn. Ars. Bapt. Bell. both. BRY. Bufo calc-ar. Calc-f. CALC. carb-v. carbn-s. Cham. Chin. chlorpr. Crot-h. eberth. Ferr-p. graph. Ham. hecla hep. Hippoz. hir. Iod. Kali-c. kali-chl. kali-m. kreos. LACH. Led. Lyc. Lycps-v. mag-c. mag-f. merc-cy. merc-i-r. merc. morg-p. Mur-ac. Nat-s. nux-v. parathyr. phos. prot. Puls. rhod. RHUS-T. Sep. Sil. spig. streptoc. stront-br. stront-c. sulfa. Sulph. thiop. thuj. verat. vip-a. VIP. zinc.

GENERALS - INFLAMMATION - Blood vessels- acon. Ant-t. apis ARN. ars-i. ARS. aur. BAR-C. BELL. bufo calc. canth. carb-v. cham. chin. Cupr. Ham. hell. Kali-c. kreos. lach. lyc. nux-v. Puls. rhus-t. sep. sil. spig. SULPH. thuj. Verat-v. VERAT. VIP. zinc.

GENERALS - OBESITY - children; in- Ant-c. Bad. bar-c. bell. Brom. CALC. Caps. cina Coloc. Ferr. graph. guaj. Ip. Kali-bi. kali-c. puls. sacch. sars. seneg. sulph.

GENERALS - OBESITY – flabby- lac-d.

GENERALS - OBESITY - Legs thin; body fat but- am-c. Am-m. ant-c. graph. lith-c. plb.

GENERALS – OBESITY- Acon. adam. adon. agar. ail. alco. all-s. Am-br. Am-c. am-caust. am-f. Am-m. ambr. ANAC. Ang. Ant-c. ant-t. apis aq-mar. aran-ix. Arg-n. arist-cl. arn. Ars. Asaf. aur-m. aur-s. Aur. bac. bar-br. bar-c. bar-i. bar-met. Bell. berb. bism-sn. blatta-o. borx. brom. bry. bufo calad. calc-act. Calc-ar. calc-caust. calc-lac. calc-m. calc-met. calc-o. Calc-p. calc-s. CALC. Calo. camph. canth. CAPS. carb-v. carc. Carl. caust. cham. chin. chlorpr. chr-m. chr-met. chr-s. cic. cimic. cinnb. clem. Coc-c. coca cocc. coloc. con. cortiso. Croc. crot-h. Cupr. cyna. dig. dulc. Elaps euph. euphr. falco-pe. ferr-i. Ferr-n. FERR. Fuc. gamb. gink-b. glycyr-g. GRAPH. guaj. hafn-met. hell. Hura Hyos. ign. iod. ip. irid-met. Kali-bi. kali-br. Kali-c. kali-met. kola lac-c. Lac-d. lac-h. lach. lanth-met. laur. lith-c. lith-f. lith-i. lith-met. lith-p. lith-s. lob-e. lob. Lyc. lycpr. mag-c. Mag-n. mag-p. mang-act. Mang-n. med. merc-d. merc-i-f. merc. moly-met. mur-ac. nat-ar. nat-c. NAT-M. nicc-met. nicc-s. Nitro. nux-m. nux-v. olnd. op. osm-met. ozone pert-vc. Phos. PHYT. pitu-a. plat. plb-m. plb-p. plb. positr. Puls. rauw. rhen-met. rheum rhus-t. rumx. ruta sabad. sabal sacch. sars. sel. seneg. sep. sil. spig. spong. staph. stram. stront-c. stroph-h. Sulph. tant-met. thal-met. thuj. Thyr. Thyroiod. tung-met. tus-fr. valer. vanil. verat. viol-o. Zinc-n.

GENERALS – OSTEOPOROSIS- arg-met. bacls-7. calc-f. cortico. cortiso. dys. fl-ac. morg-p. palo.

GENERALS - RELAXATION – physical- acon. Aeth. agar. agn. agra. aids. alet. aloe alum. ant-c. ant-t. aran. arn. ars. asar. aster. aur. bar-c. bell. bism. borx. bov. bry. calc. camph. Caps. caust. cham. chel. chin. cic. cina cocc. coff. colch. coli. cory. cupr. cycl. cystein-l. dig. dulc. euph. ferr. fuma-ac. gels. graph. hell. hep. hydr-ac. hydrog. hyos. ign. ip. kali-c. kali-n. ketogl-ac. Lac-h. lach. lil-t. linu-c. lob. lyc. Mag-c. mangi. med. meny. merc-cy. merc. micr. morph. MUR-AC. nat-c. Nat-chl. nat-m. nit-ac. nux-m. nux-v. olnd. op. oxal-a. par. Passi. petr. ph-ac. phos. plat. plb. ran-s. rhod. rhus-t. ribo. ruta sabad. sabin. sel. seneg. sep. sil. spig. spong. stann. staph. stram. streptoc. suis-pan. sulph. tarax. tritic-vg. tub. ulm-c. valer. vanil. verat. viol-o. viol-t. zinc.

GENERALS - TUMORS - atheroma, steatoma- Agar. ant-c. anthraci. arg-n. Bar-c. Bell. benz-ac. brom. Calc. caps. caust. clem. Con. crat. GRAPH. Guare. Hep. kali-br. Kali-c. kali-i. lac-ac. lach. Lob. lyc. m-arct. mez. nat-c. Nit-ac. Ph-ac. Phyt. plb. rhus-t. Sabin. Sil. spong. staph. Sulph. thuj. vanad.

GENERALS - WALKING - learning to walk – late- acon. Agar. all-s. arg-n. ars-s-f. Ars. aur-m-n. Bar-c. bell. calc-f. CALC-P. CALC. Carb-v. CAUST. cupr. ferr. fl-ac. kali-i. lil-t. lyc. mag-c. med. merc. NAT-M. Nit-ac. nux-v. Ph-ac. Phos. pin-s. Sanic. sep. Sil. sulph. thlas. thuj.

MALE GENITALIA/SEX - ATROPHY – Penis- agar. aloe amyg. ant-c. arg-met. Arg-n. Berb. caj. Cann-i. carbn-s. IGN. LYC. merc-sul. merc. op. pic-ac. plb. staph.

MALE GENITALIA/SEX - ATROPHY – Testes- agn. ant-c. ant-o. antho. Arg-n. aur-i. Aur. bar-c. bufo Caps. Carb-an. carbn-s. cerc-s. cere-s. chim. con. Gels. ign. Iod. kali-br. KALI-I. Lyss. meph. plb. Rhod. sabal staph. testis vanil. x-ray zinc.

MALE GENITALIA/SEX – ATROPHY- ant-c. arg-n. bamb-a. BAR-C. bufo carb-an. cer-s. cere-s. iod. kali-i. lyc. phos. staph.

MALE GENITALIA/SEX - CRYPTORCHISM – Prepubic- aur-m. aur. Bar-c. calc-f. calc-p. calc. caust. Con. Fl-ac. Syph. thyr.

MALE GENITALIA/SEX – CRYPTORCHISM- aloe aur. bufo iod. psor. sil. syph. Thyr. tub.

MALE GENITALIA/SEX - RETRACTION – Testes- agar. Agn. alum. alumn. arg-n. aur. Bar-c. bell. Berb. brom. bufo calc-act. Calc. camph. Cann-s. Canth. chin. cic. CLEM. coloc. crot-t. euphr. iod. M-aust. meny. Merc. nit-ac. Nux-v. ol-an. op. par. pareir. petr-ra. phos. pitu-a. Plb. psor. puls. Rhod. sabal sec. sil. Stram. sulph. syph. thuj. thyr. tub. Zinc.

MIND - MOOD – changeable- abrom-a. acon-l. Acon. adam. agar. agath-a. agn. alco. aloe alum-p. alum-sil. Alum. am-c. ambr. anac. anan. androc. ang. anh. ant-c. ant-m. Ant-met. ant-t. Apis arg-met. Arg-n. arg-p. arn. ars-h. ars-i. Ars. asaf. asar. astra-e. aur-i. Aur-m-n. aur-m. aur-s. Aur. bac. bamb-a. Bar-act. Bar-c. bar-i. Bell. bism-sn. bism. Borx. bov. brucel. bry. bufo buth-a. cadm-met. cadm-s. calc-s. calc-sil. Calc. camph-mbr. cann-i. cann-s. canth. caps. carb-an. carb-v. carbn-o. carbn-s. Carc. carl. cassia-s. castm. caul. caust. cerstig-w. cham. Chin. chir-fl. choc. chr-met. chr-s. cic. cimic. cina cob. coc-c. coca coca-c. Cocc. Coff. con. cortico. Croc. Cupr. cur. cycl. cygn-be. cypra-eg. Des-ac. Dig. dioxi. dros. emb-r. eup-per. falco-pe. ferr-ar. ferr-i. Ferr. form. fum. gels. gink-b. graph. guare. heroin. hyos. IGN. iod. ip. irid-met. Kali-c. kali-p. kali-s. kali-sil. Kola lac-c. lac-d. lac-h. lac-leo. lac-loxod-a. lac-mat. lach. lachn. laur. led. lil-t. limest-b. lith-i. luna LYC. m-arct. m-aust. Mag-c. mang-act. mang-i. med. melal-alt. meny. merc-c. merc-i-f. Merc. mez. Moni. morph. mosch. mur-ac. nat-c. nat-m. neon nid. nit-ac. NUX-M. nux-v. onop. op. ozone Petr. ph-ac. phel. Phos. pitu-gl. plac-s. plan. Plat. plb. propr. Psor. PULS. pulx. ran-b. rat. rheum rhod. rhus-g. Rhus-t. rubd-met. sabad. sal-fr. sang. sanic. sapin. SARS. scler. senec. seneg. Sep. ser-a-c. sil. spect. spig. spong. Stann. Staph. Stram. streptoc. suis-em. Sul-ac. sul-i. sulph. Sumb. suprar. Symph. Syph. tab. taosc. tarent. tax. thal-xyz. thiam. thuj. Tub. Valer. vanil. verat. verb. viol-o. yuc. zinc-i. zinc-m. zinc-n. zinc-p. Zinc-val. ZINC. ziz.

MIND – OBSTINATE- abrot. Acon. act-sp. Agar. alco. aloe alum-p. alum-sil. ALUM. alumn. am-c. am-m. ambr. ANAC. androc. Ant-c. ant-m. ant-t. apis ARG-N. arizon-l. arn. ars-s-f. Ars. arum-t. aur-ar. aur-m-n. aur-s. aur. bamb-a. bar-act. bar-c. bell-p-sp. BELL. bism-sn. bora-o. Bry. bufo caes-met. calc-ar. calc-p. Calc-s. CALC. camph. canth. Caps. carb-an. carb-v. carbn-s. carc. Caust. CHAM. chel. Chin. chinin-s. chir-fl. choc. Cina coca coloc. croc. Crot-h. cupr. cycl. cygn-be. dendr-pol. des-ac. dig. dros. Dulc. emb-r. euph. ferr-ar. ferr-p. ferr. galv. gard-j. guaj. hell. Hep. hura hydrog. Hyos. Ign. ignis-alc. ip. kali-ar. kali-bi. Kali-c. kali-chl. kali-i. kali-m. Kali-p. kali-s. kali-sil. kalm. kreos. lac-e. lac-f. lach. Lyc. Mag-m. Med. medul-os-si. menis. merc. mez. morph. mosch. mur-ac. nat-c. nat-m. nat-sil. nicc-met. Nit-ac. NUX-V. oscilloc. osm-met. oxyg. p-benzq. Pall. pert-vc. petr. Ph-ac. phel. phos. plat. plb. positr. Prot. Psor. puls. rhus-t. ruta ruth-met. sanic. sec. sep. Sil. Spong. Staph. stram. Sulph. Symph. syph. TARENT. tax. Thuj. thymol. Tub. verat. viol-o. viol-t. zinc-p. zinc.

MIND - RETARDATION; mental – children- aur. bufo Carc. iod. lyc. merc. phos. plb. sil. sulph. tub. zinc.

MIND - RETARDATION; mental- ambr. ars-i. aur. bar-m. Bufo carc. cic. des-ac. iod. kali-br. lyc. merc. pert. phos. plb. sil. sulph. syph. Tub. zinc.

MIND - THOUGHTS – compelling- Anac. anh. ant-c. arg-n. Ars. aur. bell-p. brom. calc. carb-v. carc. Caust. con. cupr-act. cupr. foll. HYOS. Ign. Iod. kali-c. lac-c. Lach. lyss. manc. MED. merc. nat-m. Nat-s. nit-ac. Nux-v. passi. phos. pin-s. Plat. psor. puls. Rat. rhus-t. sil. Staph. sulph. Syph. thuj. tub. verat.

RESPIRATORY SYSTEM - Respiration – Arrested- ars. bov. camph. hydr-ac. Lat-m. lyss. upa.

SKIN – INTERTRIGO- acon. Aeth. agn. Am-c. Ambr. ant-t. arist-cl. arn. ars. Bar-c. bell. Borx. Calc-s. calc-sil. calc. Carb-v. CAUST. Cham. Chin. fago. GRAPH. Hep. Hydr. Ign. jug-r. kali-ar. kali-br. Kali-c. kali-chl. kali-m. kali-s. kali-sil. KREOS. Lyc. Mang. Merc. mez. Nat-m. nat-p. nat-s. Nit-ac. nux-v. ol-an. olib-sac. olnd. ox-ac. Petr. ph-ac. phos. Phyt. plb. psor. puls. rhus-t. ruta sabin. Sep. Sil. squil. Sul-ac. SULPH. syph. tub. zinc-o.

STOMACH - APPETITE - capricious appetite- ail. alum-sil. ang. arizon-l. arn. ars. arum-t. aster. bar-c. bell. bit-ar. BRY. bufo calad. calc. Carb-an. carbn-s. carc. cham. CHIN. chir-fl. choc. Cimic. CINA Coc-c. coca coli. croc. fago. ferr. gran. graph. Hep. IGN. Iod. Ip. irid-met. kali-bi. kali-s. kreos. lac-loxod-a. Lach. limen-b-c. luna mag-c. Mag-m. mang-p. merc-i-f. merc. nat-m. nux-m. nux-v. petr-ra. petr. Phos. PULS. rheum rhus-g. rhus-t. ruta sabal Sang. sil. spong. staph. sulph. sumb. suprar. sym-r. symph. syph. tep. Ther. tritic-vg. Tub. zinc-chl. zinc-p. zinc.

STOMACH - APPETITE – constant- bamb-a. bov. calc-p. cocc. fl-ac. gran. Kali-bi. kali-p. Merc. moni. musca-d. myric. Nat-c. Nat-m. plut-n. psil. rat. tab.

STOMACH - APPETITE - eating; even after- allox. cic. sacch. spong. tritic-vg.

STOMACH - APPETITE – increased- ABIES-C. abrom-a. abrot. acal. acon-ac. Acon. adam. Agar. agath-a. agn. Aids. ail. alf. All-c. all-s. allox. aloe alum-p. alum-sil. Alum. Alumn. AM-C. am-m. anac. anan. androc. ang. anh. ant-c. ant-m. ant-met. ant-t. Aq-mar. ara-maca. ARG-MET. arist-cl. arizon-l. arn. Ars-i. ARS. asaf. asar. aster. atp. aur-i. Aur. bac. Bapt-c. Bar-c. Bar-i. Bar-m. bar-ox-suc. bell-p-sp. bell-p. Bell. Berb. beryl. bism. bit-ar. borx. bov. brass-n-o. bros-gau. bry. bung-fa. cadm-met. calad. calc-i. Calc-p. CALC-S. calc-sil. CALC. camph. CANN-I. cann-s. canth. caps. carb-ac. Carb-an. carb-v. carbn-s. caul. Caust. cham. CHIN. Chinin-s. choc. chord-umb. cic. CINA CINNB. cit-ac. clem. cob-n. coc-c. coca-c. Cocc. coff. colch. coli. coloc. Con. cop. corian-s. cortiso. corv-cor. crot-c. cub. cupr. cycl. cygn-be. cypra-eg. cystein-l. des-ac. dig. dios. dream-p. dros. dulc. Elaps ephe-si. equis-h. eug. euph. euphr. falco-pe. Ferr-ar. Ferr-i. Ferr. Fl-ac. flor-p. fum. galeoc-c-h. galla-q-r. gamb. Gels. gent-c. ger-i. germ-met. glycyr-g. gran. GRAPH. grat. Guaj. Guare. haliae-lc. hed. hell. helo-s. helodr-cal. hep. heroin. hir. hura hydr-ac. hydr. hydrog. hyos. Ign. ind. IOD. jug-c. jug-r. kali-ar. kali-bi. kali-br. kali-c. kali-chl. kali-i. kali-m. kali-n. kali-p. Kali-s. kreos. Lac-ac. Lac-c. Lac-h. Lac-loxod-a. lac-lup. Lach. lact. laur. led. lept. lil-t. limen-b-c. limest-b. luf-op. LYC. lyss. m-ambo. m-arct. m-aust. mag-c. mag-i. Mag-m. mag-p. maias-l. mand. mang-p. mang. marb-w. med. meny. Merc-c. Merc. mez. mosch. mucs-nas. Mur-ac. Myric. nad. Nat-ar. Nat-c. nat-i. NAT-M. nat-ox. Nat-p. nat-pyru. Nat-s. neon nicotam. Nit-ac. Nux-m. NUX-V. oci-sa. olib-sac. OLND. oncor-t. onos. Op. orot-ac. osteo-a. ox-ac. oxal-a. ozone pant-ac. par. Pert-vc. petr-ra. PETR. Ph-ac. PHOS. phys. Pic-ac. pin-con. plac-s. plat. plb. plut-n. podo. polys. positr. propl. propr. pseuts-m. PSOR. ptel. PULS. pycnop-sa. pyrid. ran-b. raph. Rat. rauw. rein. rheum rhod. rhus-g. rhus-t. ribo. ros-d. ruta SABAD. sal-al. sal-fr. sars. sec. sel. seneg. Sep. Sil. skat. spect. spig. spong. squil. Stann. Staph. stram. stront-c. succ-ac. suis-em. suis-hep. suis-pan. sul-ac. sul-i. sulfonam. SULPH. sumb. symph. tab. taosc. tarent. tax. tep. ter. tetox. Teucr. ther. thiam. thuj. thymol. tritic-vg. tung-met. ust. valer. vanil. VERAT. verb. vero-o. vip. visc. xan. zinc-p. zinc.

STOMACH - APPETITE – insatiable- abies-c. aids. allox. androc. ang. anh. ant-c. Arg-met. arg-n. arum-t. asc-t. aur. bamb-a. bar-c. bell-p. Bell. bung-fa. cadm-met. Cic. cina cypra-eg. dulc. Ferr-i. Ferr. hydrog. ign. IOD. Kola lil-t. limest-b. LYC. marb-w. merc. Moni. nat-pyru. nauf-helv-li. ozone petr. plat. propl. puls-n. puls. rauw. rhus-g. Sec. Sep. Spong. squil. stann. staph. thuj. tub. ulm-c. v-a-b. visc. Zinc.

STOMACH - APPETITE – ravenous- abies-c. abrot. acet-ac. adon. Agar. agath-a. agn. Alf. All-c. all-s. allox. alum-p. alum-sil. Alum. AM-C. am-m. Anac. anan. ang. ant-t. aq-mar. ara-maca. ARG-MET. arn. ars-br. ARS-I. ars-s-f. ARS. asaf. aur-ar. aur-i. aur-s. Aur. bac. bamb-a. bar-c. Bar-i. bar-m. bar-s. bell. Berb. bov. brass-n-o. brass. Bry. cact. calad. calc-i. CALC-P. CALC-S. calc-sil. CALC. calen. camph. CANN-I. cann-s. cann-xyz. caps. carb-ac. Carb-an. carb-v. CARBN-S. carc. card-m. cartl-s. cassia-s. caul. Caust. cham. chel. CHIN. Chinin-ar. chinin-s. chir-fl. Cic. cimic. CINA clem. clerod-i. Coc-c. Cocc. Coff. Colch. Coloc. Con. conch. cop. corian-s. Corv-cor. crot-c. cupr. cygn-be. cypra-eg. dros. dulc. Elaps equis-h. Eup-per. falco-pe. Ferr-ar. Ferr-i. ferr-p. FERR. Fl-ac. galla-q-r. gamb. gels. glyc. gran. GRAPH. Guaj. guare. hell. hep. heroin. hura hydrog. Hyos. ichth. Ign. ind. IOD. irid-met. jug-c. kali-ar. kali-bi. kali-c. kali-chl. kali-m. Kali-n. kali-p. kali-s. kali-sil. Kola kreos. Lac-ac. lac-c. lach. lap-a. lap-la. laur. lil-t. lith-i. lob. LYC. lyss. m-ambo. m-arct. m-aust. mag-c. mag-m. mag-p. mang-i. marb-w. medul-os-si. melal-alt. meny. Merc-c. merc-i-f. Merc. Mez. Moni. Mur-ac. myric. Nat-ar. Nat-c. NAT-M. nat-ox. Nat-p. Nat-s. nat-sil. nicotam. Nit-ac. Nux-m. NUX-V. Ol-j. Olib-sac. OLND. Op. osteo-a. ox-ac. par. petr-ra. PETR. petros. Ph-ac. PHOS. phys. pime. Plat. plb. Podo. positr. psil. PSOR. ptel. PULS. pycnop-sa. pyrid. Rat. rhus-g. Rhus-t. ros-d. rumx. ruta SABAD. sanic. Sec. sel. seneg. Sep. SIL. sphing. spig. Spong. squil. Stann. Staph. stront-c. sul-ac. sul-i. SULPH. tab. tarent. tep. ter. teucr. ther. Thuj. Thyr. tritic-vg. tub. Uran-n. ust. valer. vanil. VERAT. visc. zinc-i. zinc-p. zinc.

Homoeopathic remedies in decreasing order of indication in Prader Willi Syndrome—

 

  1. bar-c.
  2. sil.
  3. merc.
  4. sulph.
  5. calc.
  6. lyc.
  7. phos.
  8. plb.
  9. iod.
  10. aur.
  11. ant-c.
  12. bell.
  13. ars.
  14. caust.
  15. lach.
  16. nat-m.
  17. nux-v.
  18. puls.
  19. rhus-t.
  20. staph.
  21. bufo
  22. kali-c.
  23. sep.
  24. thuj.
  25. tub.
  26. zinc.
  27. carb-v.
  28. con.
  29. agar.
  30. arg-n.
  31. calc-p.
  32. chin.
  33. cupr.
  34. ferr.
  35. graph.
  36. ign.
  37. spong.
  38. acon.
  39. arn.
  40. carbn-s.
  41. cic.
  42. nit-ac.
  43. syph.
  44. bry.
  45. cham.
  46. med.
  47. op.
  48. petr.
  49. ph-ac.
  50. psor.
  51. verat.
  52. ant-t.
  53. caps.
  54. carc.
  55. dulc.
  56. hep.
  57. kreos.
  58. mag-c.
  59. nat-c.
  60. ruta
  61. spig.
  62. am-c.
  63. apis
  64. cina
  65. coloc.
  66. hyos.
  67. kali-p.
  68. mur-ac.
  69. agn.
  70. aloe
  71. arg-met.
  72. bamb-a.
  73. bar-m.
  74. calc-s.
  75. camph.
  76. canth.
  77. carb-an.
  78. clem.
  79. cocc.
  80. ferr-i.
  81. fl-ac.
  82. kali-br.
  83. plat.
  84. stram.
  85. thyr.
  86. alum.
  87. anac.
  88. bov.
  89. dig.
  90. dros.
  91. gels.
  92. guaj.
  93. hell.
  94. ip.
  95. kali-bi.
  96. kali-i.
  97. lac-d.
  98. mag-m.
  99. meny.

100.mez.

101.nat-s.

102.nux-m.

103.rat.

104.sec.

105.seneg.

106.stront-c.

107.tarent.

108.tritic-vg.

109.vanil.

110.allox.

111.alum-sil.

112.am-m.

113.ang.

114.arist-cl.

115.ars-i.

116.aur-s.

117.borx.

118.calc-f.

119.calc-sil.

120.cimic.

121.kali-ar.

122.kali-chl.

123.kali-m.

124.kali-s.

125.lac-c.

126.lil-t.

127.lyss.

128.olnd.

129.rhod.

130.sabad.

131.sanic.

132.sars.

133.squil.

134.sul-ac.

135.valer.

136.zinc-p.

137.all-s.

138.alumn.

139.ambr.

140.androc.

141.asaf.

142.bac.

143.bar-i.

144.berb.

145.brom.

146.cann-i.

147.cann-s.

148.caul.

149.chel.

150.coc-c.

151.coca

152.coff.

153.cortiso.

154.croc.

155.crot-h.

156.cycl.

157.ferr-ar.

158.ferr-p.

159.guare.

160.hydrog.

161.laur.

162.led.

163.m-arct.

164.m-aust.

165.mag-p.

166.merc-c.

167.moni.

168.mosch.

169.nat-ar.

170.nat-p.

171.rheum

172.rhus-g.

173.sabal

174.sabin.

175.sel.

176.stann.

177.symph.

178.tab.

179.abies-c.

180.abrom-a.

181.acet-ac.

182.ail.

183.alco.

184.alum-p.

185.anan.

186.anh.

187.aur-i.

188.aur-m-n.

189.aur-m.

190.cadm-met.

191.calad.

192.calc-ar.

193.calc-i.

194.chinin-s.

195.choc.

196.colch.

197.cortico.

198.des-ac.

199.euph.

200.gran.

201.ham.

202.helon.

203.hura

204.hydr-ac.

205.irid-met.

206.kali-n.

207.kali-sil.

208.kola

209.lac-ac.

210.lob.

211.merc-i-f.

212.morph.

213.ox-ac.

214.pic-ac.

215.podo.

216.rauw.

217.sang.

218.sul-i.

219.ter.

220.ther.

221.ust.

222.viol-o.

223.vip.

224.visc.

225.lac-h.

226.ozone

227.chir-fl.

228.positr.

229.falco-pe.

230.petr-ra.

231.cygn-be.

232.cypra-eg.

233.abrot.

234.alf.

235.all-c.

236.ant-m.

237.aq-mar.

238.ars-s-f.

239.arum-t.

240.asar.

241.aster.

242.aur-ar.

243.bar-act.

244.bell-p.

245.bism-sn.

246.bism.

247.carb-ac.

248.carl.

249.cere-s.

250.chim.

251.chlorpr.

252.cob-n.

253.coli.

254.cop.

255.cub.

256.elaps

257.equis-h.

258.eup-per.

259.euphr.

260.gamb.

261.hydr.

262.lat-m.

263.lith-c.

264.lith-i.

265.mang-act.

266.mang.

267.morg-p.

268.myric.

269.nat-sil.

270.oxal-a.

271.par.

272.phys.

273.phyt.

274.pin-s.

275.plan.

276.ran-b.

277.ribo.

278.rumx.

279.sacch.

280.senec.

281.streptoc.

282.sulfonam.

283.sumb.

284.tax.

285.tep.

286.uran-n.

287.verb.

288.viol-t.

289.x-ray

290.limest-b.

291.marb-w.

292.plut-n.

293.aids.

294.adam.

295.arizon-l.

296.heroin.

297.lac-loxod-a.

298.nat-pyru.

299.olib-sac.

300.suis-pan.

301.galla-q-r.

302.pert-vc.

303.agath-a.

304.adon.

305.aeth.

306.alet.

307.ant-met.

308.apoc.

309.aran-ix.

310.ars-br.

311.bapt.

312.benz-ac.

313.both.

314.brass-n-o.

315.bung-fa.

316.buth-a.

317.cact.

318.calc-act.

319.calen.

320.card-m.

321.castm.

322.chinin-ar.

323.chlol.

324.chr-met.

325.chr-s.

326.cinnb.

327.conch.

328.corian-s.

329.crot-c.

330.cupr-act.

331.cur.

332.dam.

333.dios.

334.emb-r.

335.eup-pur.

336.fago.

337.flor-p.

338.fum.

339.fuma-ac.

340.gink-b.

341.glyc.

342.glycyr-g.

343.grat.

344.hecla

345.hed.

346.hir.

347.hydrang.

348.ind.

349.jug-c.

350.jug-r.

351.kalm.

352.lept.

353.lith-f.

354.luna

355.lycpr.

356.lycps-v.

357.m-ambo.

358.mag-s.

359.mand.

360.mang-i.

361.mang-p.

362.merc-cy.

363.merc-d.

364.merc-sul.

365.nat-lac.

366.nat-ox.

367.nicc-met.

368.nicotam.

369.ol-an.

370.ol-j.

371.ov.

372.oxyg.

373.pareir.

374.passi.

375.phel.

376.pitu-a.

377.propl.

378.propr.

379.prot.

380.psil.

381.ptel.

382.pyrid.

383.rad-br.

384.rhus-a.

385.ros-d.

386.sapin.

387.still.

388.suprar.

389.tarax.

390.teucr.

391.thiam.

392.thymol.

393.tung-met.

394.ulm-c.

395.vanad.

396.vib.

397.zinc-i.

398.zinc-n.

399.osteo-a.

400.cassia-s.

401.neon

402.coca-c.

403.plac-s.

404.ser-a-c.

405.osm-met.

406.corv-cor.

407.suis-em.

408.chord-umb.

409.limen-b-c.

410.cystein-l.

411.medul-os-si.

412.oncor-t.

413.absin.

414.aca

 

Bibliography

Prader–Willi and Angelman Syndromes Fitzpatrick's Dermatology in General Medicine, 8e > Chapter 73. Albinism and Other Genetic Disorders of Pigmentation

Imprinting Disorders Harrison's Online > Chapter 62. Chromosome Disorders > Chromosomal Syndromes

Other Chromosomal Dysgeneses Adams and Victor's Neurology > Chapter 38. Developmental Diseases of the Nervous System > Chromosomal Abnormalities (Karyotypic Chromosomal Dysgeneses)

Prader-Willi Syndrome Harrison's Online > Chapter 339. Disorders of the Anterior Pituitary and Hypothalamus > Hypothalamic and Anterior Pituitary Insufficiency > Developmental and Genetic Causes of Hypopituitarism

Prader-Willi and Angelman Syndromes Williams Hematology, 8e > Chapter 10. Genomics and Epigenetics > Genomics and Epigenetics > Genomic Imprinting

Miscellaneous Disorders Greenspan’s Basic & Clinical Endocrinology, 9e > Chapter 15. Puberty > Delayed Puberty or Absent Puberty (Sexual Infantilism) > Hypogonadotropic Hypogonadism

Prader-Willi Syndrome CURRENT Diagnosis & Treatment: Pediatrics > Chapter 35. Genetics & Dysmorphology > Nonmendelian Disorders > Disorders of Imprinting

X-Inactivation, Imprinting, and Uniparental Disomy Harrison's Online > Chapter 61. Principles of Human Genetics > Impact of Genetics on Medical Practice > Transmission of Genetic Disease > Exceptions to Simple Mendelian Inheritance Patterns

Prader-Willi Syndrome Greenspan’s Basic & Clinical Endocrinology, 9e > Chapter 6. Growth > Disorders of Growth > Short Stature Due to Nonendocrine Causes > Syndromes of Short Stature

Growth Hormone Treatment of Pediatric Patients with Short Stature Basic & Clinical Pharmacology, 12e > Chapter 37. Hypothalamic & Pituitary Hormones > Anterior Pituitary Hormones & Their Hypothalamic Regulators > Anterior Pituitary & Hypothalamic Hormone Receptors > Growth Hormone (Somatotropin) > Clinical Pharmacology

Prader–Willi and Angelman Syndromes Fitzpatrick's Dermatology in General Medicine, 8e > Chapter 73. Albinism and Other Genetic Disorders of Pigmentation > Etiology, Pathogenesis, and Clinical Features > Etiology, Pathogenesis, and Clinical Features of Albinism

Smith's General Urology > Chapter 44. Male Infertility > Causes of Male Infertility > Pretesticular > Hypothalamic Disease

Prader-Willi syndrome is characterized by obesity, hypotonic musculature, mental retardation,... Harrison's Online > Chapter 346. Disorders of the Testes and Male Reproductive System > Disorders of the Male Reproductive Axis during Adulthood > Hypogonadotropic Hypogonadism > Congenital Disorders Associated with Gonadotropin Deficiency

A number of complex human syndromes with defined inheritance are associated with obesity (Table... Harrison's Online > Chapter 77. Biology of Obesity > Biology of Obesity: Introduction > Specific genetic syndromes

GH is approved for treatment of growth failure in Prader-Willi syndrome. Many affected individuals... CURRENT Diagnosis & Treatment: Pediatrics > Chapter 32. Endocrine Disorders > Disturbances of Growth > Short Stature > Short Stature Associated with Syndromes

Encyclopedia Homoeopathica

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Comment by Dr Rajneesh Kumar Sharma MD(Hom) on November 26, 2012 at 10:37pm

Thanks Dr. Sharad for adding new remedies.

Comment by Dr Rajneesh Kumar Sharma MD(Hom) on November 26, 2012 at 10:37pm

Thanks with regards Dr. Shangloo.

Comment by Dr.Sharad Shangloo on November 26, 2012 at 8:27am

Few New medicines which can be thought of is Human Growth Hormone 30c, Somatotrophin 30c, D.N.A 30C They can be given along with the constitutional remedies to see the result.

Comment by Dr.Sharad Shangloo on November 26, 2012 at 8:24am

Very nice.  Great work.

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