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'Autistic Spectrum Disorder' is commonly known as 'autism' and a person suffering from this illness is referred to as 'autistic'. It is a behavioral disorder with a number of symptoms that may range from mild to severe. No two children with autism may have exactly the same symptoms or the same experience

 

SIGN AND SYMPTOMS OF AUTISM

 

There common signs and symptoms are -

  • little or no eye contact, facial expressions, and/or body language
  • unable to form friendships with their peers
  • not willing or able to share enjoyment or accomplishments with others
  • unable to relate or share emotions on a social level
  • doesn’t talk or doesn’t use language properly
  • doesn’t respond to voices or other sounds
  • no attempt to replace language with another form of communication
  • unable to talk with another person even if they have the ability to talk
  • repeating words or having echolalia (echoing words without meaning)
  • no imaginative play (doesn’t pretend or play make-believe games)
  • obsessed with a certain topic or object
  • focused on specific routines or rituals that have no practical function
  • repetitive actions or movements like flapping, spinning, and/or body movements
  • intense preoccupation with parts of objects
  • extra sensitive to certain sounds, smells, tastes, or textures

 

PATHOPHYSIOLOGY

 

Recent studies suggest that autism's mechanism includes alteration of brain development soon after conception. Just after birth, the brains of autistic children tend to grow faster than usual, followed by normal or relatively slower growth in childhood. It seems to be most prominent in brain areas underlying the development of higher cognitive specialization.

 

The hypothetical causes of early overgrowth of brain areas occurs due to:

 

  • An excess of neurons that causes local overconnectivity in key brain regions.
  • Disturbed neuronal migration during early gestation. Neuronal migration is the method by which neurons travel from their origin or birth place to their final position in the brain.
  • Unbalanced excitatory–inhibitory networks.

 

Abnormal formation of synapses and dendritic spines, for example, by modulation of the neurexin–neuroligin cell-adhesion system, or by poorly regulated synthesis of synaptic proteins. ( A neurexin (NRXN) is a presynaptic protein that helps to glue together neurons at the synapse. Neurexins are type I membrane proteins that can be classified into two types, α-NRXNs and β-NRXNs. Neurexins mediate signaling across the synapse, and affect the properties of neural networks by specifying synaptic functions)

 

Interactions between the immune system and the nervous system begin early during the embryonic stage of life, and successful neurodevelopment depends on a balanced immune response. Aberrant immune activity during critical periods of neurodevelopment is possibly part of the mechanism of some forms of ASD.  Although some abnormalities in the immune system have been found in specific subgroups of autistic individuals, it is not known whether these abnormalities are relevant to or secondary to autism's disease processes.

 

The mirror neuron system (MNS) theory of autism hypothesizes that distortion in the development of the MNS interferes with imitation and leads to autism's core features of social impairment and communication difficulties. The MNS operates when an animal performs an action or observes another animal perform the same action. The MNS may contribute to an individual's understanding of other people by enabling the modeling of their behavior via embodied simulation of their actions, intentions, and emotions. Several studies have tested this hypothesis by demonstrating structural abnormalities in MNS regions of individuals with ASD. However, individuals with autism also have abnormal brain activation in many circuits outside the MNS. (Source-Wikipedia) 

 

ASD-related patterns of low function and aberrant activation in the brain differ depending on whether the brain is doing social or nonsocial tasks.  In autism there is evidence for reduced functional connectivity of the default network, a large-scale brain network involved in social and emotional processing, with intact connectivity of the task-positive network, used in sustained attention and goal-directed thinking. In people with autism the two networks are not negatively correlated in time, suggesting an imbalance in toggling between the two networks, possibly reflecting a disturbance of self-referential thought.   

 

SCOPE OF HOMEOPATHY TREATMENT IN AUTISM

 

The scope of homeopathy treatment in autism spectrum disorder (ASD) is very good. It is because homeopathy treats the patient as a whole. The proper constitutional homeopathy treatment basing upon the existing physical, mental, psychological and behavioral symptoms can cure the autistic spectrum disorder successfully. No autism child is similar to another autism child in the symptoms or behavior wise. Everyone has their own individualize characteristic symptoms and the homeopathy treatment also targets the individual characteristic symptoms of every case of ASD child and treats accordingly. The success rate is very good in ASD by proper homeopathy treatment.

There are some hypothetical pathophysiological explanation how homeopathy helps in ASD. After birth, the brains of autistic children tend to grow faster than usual, followed by normal or relatively slower growth in childhood. This is because abnormal formation of synapses and dendritic spines caused by modulation of the neurexin–neuroligin cell-adhesion system, or by poorly regulated synthesis of synaptic proteins, neurexin (NRXN). A neurexin (NRXN) is a presynaptic protein that helps to glue together neurons at the synapse. Neurexins mediate signaling across the synapse, and affect the properties of neural networks by specifying synaptic functions. Thus in this stage the proper constitutional homeopathy remedies help to maintain the normal NRXN level by enhancing its synthesis or fixing the abnormalities in neurexin–neuroligin cell-adhesion system, thus help normal synapse formation and maintain normal signaling across the synapse. So helps in normal functioning of that part of brain by a continue constitutional homeopathy treatment.

The immune system and nervous system are closely interrelated to each other. Any aberrant immune activity during critical periods of neurodevelopment is possibly part of the mechanism of some forms of ASD. Thus a successful neurodevelopment depends on a balanced immune response. A constitutional homeopathy treatment modulates the body immune system as the minute dose of homeopathy works at the dynamic level in the body. Thus it helps to keep a good link between immune system and nervous system and helps in autism case for a normal development of brain.

 

Autism linked to high fructose corn syrup

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