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Trituration is a process of potentisation by which preparations of each medicine takes place using a solid vehicle, like sugar of milk, and grinding in definite order according to Pharmacopoeia. Drug substances are triturated up to 3C or 6X. These are then converted to a liquid potency and further potentisation is carried out by the process of succussion.
Substances that are insoluble in a liquid vehicle like alcohol and water are triturated. These drugs belong to Class VII, Class VIII and Class IX of the Old method.
Vehicle for Trituration
Sugar of milk is used for the process of trituration because the preservative properties of sugar of milk are superior to cane sugar and most other substances. Its crystalline particles are very hard and gritty and hence are of great use in grinding down the particles of drugs during trituration.