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When there is a genetic immune deficiency disease, can Homeopathy Help?

WIKIPEDIA | Osteogenesis imperfecta

Osteogenesis imperfecta (OI and sometimes known as Brittle Bone Disease, or "Lobstein syndrome"[1]) is a genetic bone disorder. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen.[2] This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. The larger amino acid side-chains create steric hindrance that creates a "bulge" in the collagen complex, which in turn influences both the molecular nanomechanics as well as the interaction between molecules, which are both compromised [3]. As a result, the body may respond by hydrolyzing the improper collagen structure. If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals to form bone is altered, causing brittleness [4]. Another suggested disease mechanism is that the stress state within collagen fibrils is altered at the locations of mutations, where locally larger shear forces lead to rapid failure of fibrils even at moderate loads as the homogeneous stress state found in healthy collagen fibrils is lost [5]. These recent works suggest that OI must be understood as a multi-scale phenomenon, which involves mechanisms at the genetic, nano-, micro- and macro-level of tissues.

As a genetic disorder, OI is an autosomal dominant defect. Most people with OI receive it from a parent but it can be an individual (de novo or "sporadic") mutation.


Type I

Collagen is of normal quality but is produced in insufficient quantities:

  • Bones fracture easily
  • Slight spinal curvature
  • Loose joints
  • Poor muscle tone
  • Discoloration of the sclera (whites of the eyes), usually giving them a blue-gray color. The blue-gray color of the sclera is due to the underlying choroidal veins which show through. This is due to the sclera being thinner than normal because of the defective Type I Collagen not forming correctly.
  • Early loss of hearing in some children
  • Slight protrusion of the eyes

IA and IB are defined to be distinguished by the absence/presence of dentinogenesis imperfecta (characterized by opalescent teeth; absent in IA, present in IB). Life expectancy is slightly reduced compared to the general population due to the possibility of fatal bone fractures and complications related to OI Type I such as Basilar invagination.[citation needed]


Type II

Collagen is not of a sufficient quality or quantity

Type II can be further subclassified into groups A, B, C, which are distinguished by radiographic evaluation of the long bones and ribs. Type IIA demonstrates broad and short long bones with broad and beaded ribs. Type IIB demonstrates broad and short long bones with thin ribs that have little or no beading. Type IIC demonstrates thin and longer long bones with thin and beaded ribs.


Type III

Collagen quantity is sufficient but is not of a high enough quality

  • Bones fracture easily, sometimes even before birth
  • Bone deformity, often severe
  • Respiratory problems possible
  • Short stature, spinal curvature and sometimes barrel-shaped rib cage
  • Loose joints
  • Poor muscle tone in arms and legs
  • Discolouration of the sclera (the 'whites' of the eyes)
  • Early loss of hearing possible

Type III is distinguished among the other classifications as being the "Progressive Deforming" type, wherein a neonate presents with mild symptoms at birth and develops the aforementioned symptoms throughout life. Lifespan may be normal, albeit with severe physical handicapping.


Type IV

Collagen quantity is sufficient but is not of a high enough quality

  • Bones fracture easily, especially before puberty
  • Short stature, spinal curvature and barrel-shaped rib cage
  • Bone deformity is mild to moderate
  • Early loss of hearing

Similar to Type I, Type IV can be further subclassified into types IVA and IVB characterized by absence (IVA) or presence (IVB) ofdentinogenesis imperfecta.


Type V

X-Ray OI Type V in Adult X-Ray OI Type V Kid
OI Type V leads to
calcification of the membrane between the two forearm bones, making it difficult to turn the wrist. Another symptom is abnormally large amounts of repair tissue (hyperplasic callus) at the site of fractures. At the present time, the cause for Type V is unknown, though doctors have determined that it is inherited.
Same clinical features as Type IV. Distinguished histologically by "mesh-like" bone appearance. Further characterized by the "V Triad" consisting of a) radio-opaque band adjacent to growth plates, b) hypertrophic calluses at fracture sites, and c) calcification of the
radio-ulnar interosseous membrane [6].

More on Type V Research More on OI Study

[edit]Type VI

Same clinical features as Type IV. Distinguished histologically by "fish-scale" bone appearance.

[edit]Type VII

Mutations in the gene CRTAP causes this type. [7]


Type VIII


OI caused by mutation in the gene LEPRE1 is classified as type VIII. [7]

Bisphosphonates Bisphosphonates (BPs), particularly those containing nitrogen, are being increasingly administered to increase bone mass and reduce the incidence of fracture. BPs can be dosed orally (e.g. alendronate) or by intravenous injection/infusion (e.g. pamidronate,[8] zoledronic acid).
BP therapy is being used increasingly for the treatment of OI. It has proven efficiency in reducing fracture rates in children,[9] however only a trend towards decreased fracture was seen in a small randomized study in adults.[10] While decreasing fracture rates, there is some concern that prolonged BP treatment may delay the healing of OI fractures, although this has not been conclusively demonstrated.
Pamidronate is used in USA, UK and Canada. Some hospitals, such as most Shriners, provide it to children. Some children are under a study of pamidronate. Marketed under the brand name Aredia, Pamidronate is usually administered as an intravenous infusion, lasting about three hours. The therapy is repeated every three to six months, and lasts for the life of the patient. Common side effects include bone pain, low calcium levels, nausea, and dizziness. According to recent results, extended periods of pamidrinate, (i.e.;6 years) can actually weaken bones, so patients are recommended to get bone densities every 6 months-1 year, to monitor bone strength.

Surgery
Metal rods can be surgically inserted in the long bones to improve strength, a procedure developed by Harold A. Sofield, MD, at Shriners Hospitals for Children in Chicago. During the late 1940’s, Sofield, Chief of Staff at Shriners Hospitals in Chicago, worked there with large numbers of children with OI and experimented with various methods to strengthen the bones in these children.[11] In 1959, with Edward A. Miller, MD, Sofield wrote a seminal article describing a solution that seemed radical at the time: the placement of stainless steel rods into the intramedullary canals of the long bones to stabilize and strengthen them. His treatment proved extremely useful in the rehabilitation and prevention of fractures; it was adopted throughout the world and still forms the basis for orthopedic treatment of OI.
Spinal fusion can be performed to correct scoliosis, although the inherent bone fragility makes this operation more complex in OI patients. Surgery for basilar impressions can be carried out if pressure being exerted on the spinal cord and brain stem is causing neurological problems.

Homeopathic Approaches
Thank you for listing remedies to begin our search and research for answers

Potency and Repetition Brings Varied Answers
  • As we have been discussing in the Placebo thread there is such a thing as cultural differences to how we proceed with treatment.
  • Use of low potency in frequent repetition and theory. 
  • Use of high potency with infrequent repetition.
  • Concern for aggravation. Reduction in aggravation. 
  • Use of cell salts.
  • Determining Miasm and how that effects treatment.
  • Nutrition, Diet, Supplements, Exercise.
  • Building the client / patient relationship and how that effects outcome.

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Replies to This Discussion

You should look into Calc-Flour. A good combi of Calc-Flour, Calc-Phos, Sil as an oesteo preparation in low potency.
i will say CALC-phos 6X WILL REMEDY
Calcarea Carb, Silicea, Merc sol, Phosphoric acid, Calc -phos, should help at deeper level for this.
I believe that most homeopaths provide dosage and potency recommendation on a patient to patient basis, Dr Satish. Thus, if a person is taking many allopathic drugs, it is often recommended to take the remedies in water [LM] daily with renewed succussion to change the potency vibration slightly.

Our systems have to overcome so much environmental pollutions daily, like EMF, food and water toxins, etc. that many people need to repeated dosing.

While, there are others who are so sensitive, the potency must be adjusted and fine-tuned to fit that person's energy without too much aggravation.

I am noticing how many Indian homeopaths utilize the placebo in-between major remedy changes to hold the patient through while 'waiting' for it to act.
it more to tube maism then syhil maism, peace wasalaman
dear doctors
has anyone treated Osteogenesis imperfecta?.I have treated 3 cases of such.from tht experience i can suggest u this .predominent miasm+ constituitional mediciens alone helps. i have treated successfully all thse cases and kids r still under my supervision without any medicines and any breakage of bones.just stick to basics.dont go for the misms of the diseases and pathology alone.go with themiasms of the patient.in my 2 cases they had predominent syphilitci miasm ,with familiar h/o of carcinoma and alcoholism,1 case was sycotic.and constituitional medicine has to be give with proper monitoring and less frequent repetation.ONLYHOMOEOPATHY CAN BRING CAHNGES.NOTHING ELSE
Good Drs,
Please forgive my entry into this thread as I have nothing to say concerning the pathology being discussed.

I do, however, feel strongly that when we enter into the areas of right and wrong we begin to tread on very thin ice.

Anyone can quote from theory and if the argument is simply about theory - what was said by whom and when, then right and wrong is easy to establish.

On the other hand when the discussion concerns actually experienced clinical results then the entry of right and wrong into the debate becomes really destructive.

Thus I feel it is really important to distinguish between these two forms of discussion
1] The what the theory says and
2] The what my actual experience has been.

Now it is possible to honestly discuss the relationship between these 2 and then we can all benefit.

Again, my apologies for entering into this thread as I do not know any of the contributors and am just using it as a forum to spread my opinion that strife amongst homeopaths is a much worse enemy than the allopaths or wrong prescribing.
Jonathan ~ everyone is welcome to post comments in any discussion on HWC. There are no limits. We all benefit the more people write in on blogs and forums. That is the whole purpose of social networks and by showing an interest, you become a model citizen for others to 'have their say".

Now, if a person repeats them self over and over again with the exact same message everywhere, without making a pertinent statement related to the issue at hand, then this is considered spam.

On other websites you are given the ability to RATE an article. By doing this, you create BUZZ and more activity to a particular article, which brings in more readers. We always welcome your thoughts. May many follow in your footsteps, even if it is to agree or disagree upon a point of view or topic area.
in selection of miasms pathology also plays big role,and in diferent persons distructions takes different pattern,in some breakage becomes extensive andin some its little delayed means not small injuries gives breakage of bones and the fracture doesnt become too extensive.and familial history,patients history of past etc helps in seletion of medciine as well asmiasm.
yes.dr.rana said it right.right medicine taking all the aspect of patient and diseases is called deep acting constituitional medicine.there is acute medicines which has to be given in times of need.tht is also selected on totality of tht time.give him the right medicine for the total symptoms of patient taking care of every aspect of the patient
Yes! It is right to manage the acute troubles too along with the chronic case. There are set rules. If, suppose the patient is chilly, conscientious for example and we are administering him Silicea and all of a sudden some problems occur, say, the patient suffers diarroea and thisrtlessness and dullness. We should/ought give the patient a remedy in relation to Silicea, which should/must be chilly and thirstless and conscientious. Giving a hot medicine to a chilly patient, giving a non-conscientious medicine to a conscientious patient and giving a chilly medicine to a hot patient and vice-versa will surely suppress the case and change the picture of the case and in some case may lead to the case to be incurable. I have experienced it you all may also do so and get the results I got.
Dear Debby, members:

There is still no cure for OI, however, specific therapies can reduce pain and complications associated with this disease. Nevertheless, always there is a hope with homeopathy. During the little time that i was minor resident (orthopedic surgeon) i saw several cases of OI without good results, it is very sad how this kind of children suffer a lot due to the frequent broken bones and to the pain. In my private practice i have had only two cases of OI and what i can say is, it seems to be that BPs are better tolerated (side effects) and well absorbed (it would be fine if a study could be done) when are used with homeopathy....Remedies with short sphere like Symphitum (overall for fast healing of fracture), Calc-F, Calc-P, BUT always thinking on the deeper remedy are good choices for the patient.

We should not forget (as Debby well mentioned) that Low-impact exercises such as swimming keep muscles strong and help maintain strong bones. These exercises can be very beneficial for people with OI and should be encouraged.

In severe cases, it may consider surgery to place metal rods into the long bones of the legs, in order to strengthen the bone and reduce fracture risk. Similarly, the use of orthotics (braces) may be useful for some people.

Reconstructive surgery may be needed to correct any deformities. This treatment is important because deformities such as bowed legs or a spinal problem may significantly affect a person's ability to move or walk.

Regardless of treatment, fractures occur and heal most rapidly. Should be limited time with a cast, since there may be bone loss (disuse osteoporosis) when not using a body part for a period of time.

Bet Regards
Dr. G
We ourselves don't know what Homoeopathy can do. It can and we are unaware. I agree with Debby about the low potency regime. I will recommend dietary corrections along with medicine

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