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Anti-oxidants may increase diabetes risk

VICTORIA, Australia, Oct. 12 (UPI) -- Anti-oxidants may help fight aging but Australian researchers suggest they may also increase diabetes risk.

The report, published in Cell Metabolism, found mice with a deficiency that prevented them from eliminating physiological reactive oxygen species -- free radicals linked to aging -- did not become insulin resistant on a high-fat diet as they otherwise would have. When those animals were given an anti-oxidant that fights those reactive oxygen species, those benefits were lost, leaving the mice with more signs of diabetes.

The researchers suggest low levels of reactive oxygen species -- in particular hydrogen peroxide -- might protect against diabetes by improving the body's response to insulin signals.

"Our studies indicate that 'physiological' low levels of reactive oxygen species may promote the insulin response and attenuate insulin resistance early in the progression of type 2 diabetes, prior to overt obesity and hyperglycemia," study leader Tony Tiganis of Monash University, Victoria, Australia, said in a statement. "In a way, we think there is a delicate balance and that too much of a good thing -- surprise, surprise -- might be bad

Antioxidants Could Trigger Type 2 Diabetes, So Use Them In Moderati...

But there is now mounting evidence that the situation is not as straightforward as it may seem, and like many things in biology, it is all about balance, and that small amounts of seemingly harmful substances actually play vital roles in preserving health.

For instance, studies in worms have suggested that antioxidants can reduce lifespan, and some studies in humans have suggested the same. Other research has also shown that antioxidants may counteract the longer term benefits of exercise training by lowering the activity of certain genes involved in ROS defence.

In this study, Tiganis and colleagues showedd that low levels of ROS -- and hydrogen peroxide in particular -- might actually protect us from diabetes, by improving our sensitivity to insulin signals.

Antioxidants treatment plan for diabetes
**Featured Antioxidant Diabetes Treatment**

This month we are proud to feature How To Play The Diabetes Game To Win with all natural ingredients to help balance blood sugar levels, promote circulation and effectively treat diabetes.

Diabetes Antioxidants - How can you treat diabetes?

Treatment of diabetes starts with a healthy diet and regular exercise. Your diet should be low in refined sugars, fats (especially trans fats found in deep-fried and fast food), and animal products. Your diet should be high in fiber, grains and legumes (beans, peas). Nuts are good, as are onions and garlic for maintaining blood glucose levels.

Exercise, especially aerobic like running or swimming is great for everyone, but can also help your body metabolize glucose, as well as reduce cholesterol levels and improve circulation. Exercise also helps in weight control - as we mention above obesity is a major cause of Type 2 Diabetes.

In addtion to a healthy diet and exercise, we recommend adding antioxidants as well as other important nutrients to your health program. Although you can get antioxidants from food, it may not be enough as many foods are depleted of beneficial antioxidants and your ability to use these antioxidants might be compromised if you have diabetes or are elderly.

Antioxidants Diabetes - The best antioxidants

Antioxidants are natural substances that can neutralize free radicals. Free radicals are toxic chemicals that can do serious damage to cells and tissues which can eventually lead to cancer and other diseases. So antioxidants remove these dangerous free radicals from the body.

It is widely believed that elevated blood glucose levels might lead to an increase in free radicals. It has also been shown that many people with diabetes have depleted levels of antioxidants in their bodies.

This is why supplementing antioxidants can be beneficial for diabetes sufferers, not only to maintain antioxidant levels in the body but also to treat the long-term complications that can arise.

Following are some of the many important antioxidants diabetes sufferers might benefit from:

Antioxidants Diabetes - Treating Specific Conditions

Atherosclerosis (Fatty Deposit Buildup)

Green Tea - contains the antioxidant OPC which lowers cholesterol and helps prevent blood vessel constriction.

Turmeric Extract - contains the antioxidant curcumin which that can lower LDL (bad) cholesterol and improve blood flow.

Vitamin E & Vitamin C - work together to strengthen the heart and stop the progression of artherosclerosis.

Neuropathy (Nerve Damage)

Alpha Lipoic Acid (ALA) is one of the most powerful antioxidants. It works in conjunction with Vitamin C and Vitamin E to decrease pain associated with neuropathy.

Retinopathy (Eye Damage)

Bilberry extract contains powerful antioxidants that can protect veins and arteries of the eye and prevent conditions such as macular degeneration, or damage of the retina.

Vitamin C and Vitamin E can protect the retina and maintain eye health.

Nephropathy (Kidney Damage)

Alpha Lipoic Acid (ALA) - by helping prevent atherosclerosis and improve fatty acid metabolism, ALA promotes proper kidney function.

In addition to the specific antioxidants to treat the various conditions that can arise from diabetes, it is important to maintain antioxidant levels for general health and well-being. Antioxidants are an essential part of any health regimen, for the young and old, healthy and sick alike.

Antioxidants help prevent and treat a wide range of illnesses, so you have to be sure to include antioxidants as part of a healthy nutritional program.

Antioxidants 101 ~ What and Where?

What are Antioxidants? Benefits of Antioxidants
( Antioxidants are substances or nutrients in our foods which can prevent or slow the oxidative damage to our body. When our body cells use oxygen, they naturally produce free radicals (by-products) which can cause damage. Antioxidants act as "free radical scavengers" and hence prevent and repair damage done by these free radicals. Health problems such as heart disease, macular degeneration, diabetes, cancer etc are all contributed by oxidative damage. Indeed, a recent study conducted by researchers from London found that 5 servings of fruits and vegetables reduce the risk of stroke by 25 percent. Antioxidants may also enhance immune defense and therefore lower the risk of cancer and infection.

Most Commonly Known Antioxidants

Vitamin A and Carotenoids

Carrots, squash, broccoli, sweet potatoes,tomatoes, kale,collards, cantaloupe,peaches and apricots (bright-colored fruits and vegetables!)

Vitamin C
Citrus fruits like oranges and lime etc, green peppers, broccoli, green leafy vegetables, strawberries and tomatoes

Vitamin E
Nuts & seeds, whole grains, green leafy vegetables, vegetable oil and liver oil

Fish & shellfish, red meat, grains, eggs, chicken and garlic

Other Common Antioxidants
Some common phytochemicals

Flavonoids / polyphenols
red wine
purple grapes or Concord grapes
Tomato and tomato products
pink grapefruit
dark green vegetables such as kale, broccoli, kiwi, brussels sprout and spinach
flax seed

Vitamin-like Antioxidants:
Coenzyme Q10 (CoQ10)

Antioxidant enzymes made by the body:
superoxide dismutase (SOD)
glutathione peroxidase


Every new study with mice makes the scientific world retrace their steps moving backwards and forwards. Telling people to do this or that. Take this or don't take that and every week it is something else.

I personally believe in fresh fruits and vegetables and lately have started taking Vitamin D.

We need to have clear measures that people can take to reduce the propensity to diabetes. Common sense such as reduce weight, get regular exercise and eat less sugar and processed white foods.

Are there general guidelines?

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Yes Debby, it is quite normal in modern pharmaceuticals to claim good effect of a specific formulation on human body, one day and then retreat showing adverse effect of the same medicine, after using the same years together.

In old days, there was wide spread use of iodochlorohydroxyquinoline, and after years, they claimed, that it can cause harm to optical nerves.

Similarly, Bevacizumab is the generic name for the widely used Genetech cancer drug marketed as Avastin. It inhibits tumor growth by blocking angiogenesis, the formation of new blood vessels. But according to an article just published in the June edition of The Lancet Oncology, cancer patients treated with Avastin in combination with chemotherapy are at a heightened risk of experiencing a potentially catastrophic side effect. In fact, it's a side effect that could kill them before their malignancy does -- a gastrointestinal (GI) perforation (a hole in the wall of the stomach, small intestine or large bowel).APC( Aspirin, Phenacetin, caffeine), after continuous consumption for years was discontinued, for the bad effects on GI tract.

There are many more instances.

And today it is antioxidants which may increase diabetes risk.


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